Perindopril Arginine

Perindopril is Angiotensin converting enzyme (ACE) inhibitors. It is used to treat high blood pressure also called hypertension, and it also helps prevent heart attack in people with coronary artery disease. It is prescribed as a standalone therapy or in combination with other medications to treat high blood pressure. It works by making blood flow smoother by preventing the production of certain natural chemicals that tighten the blood vessels. Perindopril Arginine is trades under the names include Coversyl, Coversum among others. Perindopril Arginine got its patent in 1980 and approved for medical use in 1988. Cipla applied for a patent with EPO in 2003 for their own preparation of their formulation and this patent was granted in 2009.

Dose and Forms:

It is sold as a tablet of 2mg, 4mg, 8mg strengths. In the treatment of Hypertension the daily recommended dose is 4-8 mg, divided over 12 hours with a Maximum of 16 mg per day. Sometimes a Diuretic is also added for careful initial titration required to avoid symptomatic hypotension. In the treatment of Stable Coronary Artery Disease , the daily recommended dose is 4 mg per day for 2 weeks, It can be increased if tolerated to 8 mg per day, as needed. To Reduce the risk of cardiovascular mortality in patients with stable CAD or Heart Failure , the dose is 2 mg per day initially to maximum 8-16 mg per day.

The price of Perindopril Arginine

In the USA, the consumers have to pay an average retail price of $148.85 for 90 tablets of 4mg strength. However in India, the same supply cost around USD 15-20.

How does it work?

Perindopril actions aid in relaxing the blood vessels relax and widen them resulting in lowering of blood pressure. The mechanism is believed to be primarily inhibition of ACE activity. ACE is a peptidyl dipeptidase used to catalyze conversion of the inactive decapeptide, angiotensin I, to the vasoconstrictor, angiotensin II. This medicine’s inhibition of ACE results in decreased plasma angiotensin II which leads to decreased vasoconstriction, increased plasma renin activity and decreased aldosterone secretion. This process eventually results in diuresis and natriuresis and can increase of serum potassium in small quantities.

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