Benzylpenicillin Potassium is classified under the drug class Natural Penicillin antibiotics and is sold under the brand names Bicillin, Bicillin L-A, and Pfizerpen among many others. Being a narrow-spectrum antibiotic, this pharmaceutical medicine is indicated for the treatment of septicemia, meningitis, pericarditis, endocarditis, and severe pneumonia. It can be commonly administered through oral, intramuscular, and subcutaneous routes in the form of tablets and injections respectively but it is mostly used in long-term injectable formulations due to its poor oral absorptions. This pharmaceutical medicine is metabolized by the liver and is eliminated through the renal route and some amount through the biliary route. It has major drug interactions with BCG vaccine, Cholera vaccine (live), Typhoid vaccine (live), and Methotrexate. Common side effects include injection site irritating reactions, twitching, upset stomach, overactive reflexes, diarrhea, nausea, vomiting, and mild skin rash. This pharmaceutical medicine is contraindicated in patients with hypersensitivity to Penicillin or who have a history of allergy to Cephalosporins, Penicillin, or any of the Beta-lactam anti-bacterial. This drug is not yet approved by the FDA for use in pregnancy and it should be only used if needed. It is secreted in human breastmilk but it can be used by lactating women but with caution.

This drug inhibits the biosynthesis of cell-wall mucopeptide and hence hinders its multiplication.

Cost of Benzylpenicillin potassium powder for injection per vial is 54.36 dollars. Price may vary among dealers.

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