Capsaicin

Capsaicin treats minor aches and pains of the muscles and joints like those in arthritis, backache, and sprains. It decreases a certain natural substance, substance P, that helps carry pain signals to the brain. Capsaicin is found in chili peppers, plants belonging to the genus Capsicum. It is a chemical irritant that produces a burning sensation in any tissue it comes into contact with. Capsaicin is a capsaicinoid and is produced as secondary metabolites by chili peppers. Capsaicin is sold under the brand names Capzasin P, Zostrix, Capzasin-HP, Axsain among others. Capsaicin is found in large quantities in the placental tissue, the internal membranes of the fruits of plants in the genus Capsicum. Capsaicin was first extracted in 1816 in an impure form by Christian Friedrich Bucholz and named it "capsicin". Karl Micko isolated capsaicin in its pure form in 1898 followed by chemical composition’s first determination in 1919. It was first synthesized in 1930 and by 1961, similar substances were isolated from chili peppers and called capsaicinoids.

Dosage and Administration

The normal course of diet may lack healthy levels of Capsaicin compound to yield all of its potential benefits. So it is taken as a supplement in higher concentrations. The general dose is 2–6 mg of capsaicin per day but this does vary by the individual’s condition and diet. Most of the supplements sold have cayenne pepper as the main active ingredient naturally high on capsaicin. Capsaicin Capsules have around 500 mg of cayenne pepper each, as each pepper contains approximately 2.5 mg of capsaicin per gram, which adds up to a dose of 2 capsules a day to get the right levels of Capsaicin in the body.

The price of Capsaicin

In the USA, the consumer can buy a Capsaicin topical cream 0.025% for around $16 for a supply of 60 grams. On the API market, In India, it is sold at USD 2465 per kilo of the ingredient.

How does Capsaicin work?

Capsaicin affects the neurotransmitter communicating pain signals to the brain by targeting the substance P. This results in the decreased perception of pain. However, Topical capsaicin acts in the skin to attenuate cutaneous hypersensitivity. This reduces the pain in a process called 'defunctionalization' of nociceptor fibers.

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