Cefoxitin

Cefoxitin is a second-generation cephamycin antibiotic. Cefoxitin is used to treat Aspiration Pneumonia, Cesarean Section, Gonococcal Infection – Uncomplicated, Intraabdominal Infection, Joint Infection, Osteomyelitis, Pelvic Inflammatory Disease, Peritonitis, Pneumonia, Septicemia, Bacterial Infection, Urinary Tract Infection, Skin and Structure Infection, Surgical Prophylaxis, Tuberculosis - Urinary Tract, Streptococcemia, Infection - Bacterial/Fungal/Protozoal/Viral and Endometritis. It is also given before surgery to prevent the development of surgical wound infections and in third and fourth-degree perineal injuries in women after giving vaginal birth. Cefoxitin decreases the infection rate at two and six weeks. Bioniche Pharma, LLC amongst others, sells Cefoxitin under the brand name Mefoxin. Merck Inc. developed Cefoxitin from Cephamycin C in the year following its discovery in 1972, when it was synthesized to create a broader spectrum antibiotic.

Dosage Forms & Strengths

Cefoxitin is available as tablets and injections. The injections are sold in three major IV doses of 1g, 2g, and 10g. In adults, Cefoxitin is administered every six to eight hours in 1g or 2g doses. In the treatment of Uncomplicated Infections, the usual recommended dose is 1 g, administered through Intravenous injections every 6 to 8 hours and for Moderate-Severe Infections, the dose is 1 g every 4 hours or 2 g every 6- 8 hours. The usual adult dose recommended in the treatment of Gas Gangrene or Infections commonly requiring antibiotics in a higher dosage is 2 g every 4 hours or 4 grams every 4 hours. For Prophylaxis post-Surgery, preventing infection post-Colorectal, non-perforated appendectomy or hysterectomy, and Ruptured viscus, the usual recommended adult dose is 1-2 g injected every 6 hours.

The price of Cefoxitin

In the USA, consumers have to pay around $430 for a supply of 10 powders for injection for 10 gm injection. In India, a supply of 1 gram of this powder in the ingredient form costs around USD25.

How does Cefoxitin work?

Cefoxitin is from a family of medicines called the beta-lactam antibiotic. This type of antibiotic binds to penicillin-binding proteins called transpeptidases. After binding to PBPs, its actions prevent PBPs from forming the cross-linkages between the peptidoglycan layers in the bacterial cell wall, interfering with cell wall synthesis. Cefoxitin is a bactericide that inhibits bacterial cell wall synthesis.

Finding Cefoxitin Manufacturers and Suppliers

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