Cerebrolysin

Cerebrolysin is a mixture of peptides extracted and purified from porcine brains. It is used to treat hemorrhagic or ischemic strokes, traumatic brain injuries, and types of forms of dementia including vascular Alzheimer’s disease and dementia, cognitive disorders and it prevents the decline of cognitive function in patients with brain injuries. Patients with either degenerative or acute neurological diseases benefit from the neuroprotective and neuro-regenerative properties of Cerebrolysin. This peptide is made using biotechnology and stimulates neurotrophic regulation of the central nervous system of the brain. It has a fast onset action that quickly regains and maintains the independence of patients suffering from stroke, TBI, cognitive impairment, and dementia. Cerebrolysin properties help improves the brain's ability to repair itself by stimulating neuro-recovery. Cerebrolysin is sold under the brand names Cerebrolysin Ebewe, Cerebrolysin EVER Neuro, Cerebrolyzin amongst others. Ever Neuro Pharma GmbH holds the patent for developing Cerebrolysin in 2017. Cerebrolysin is clinically proven and approved for use in Europe. Cerebrolysin is also approved for sale in China, Germany, Russia, and South Korea. However, the US FDA is yet to approve it for sale in the USA.

Forms and Dose:

Cerebrolysin is available as a solution for intramuscular and intravenous injections in ampoules/vials of 2, 5, 10 ml concentrations. The recommended adult dosage should in the range of 10 and 50 ml per day. It is administered by infusion with a duration of 15 minutes. For lower doses, of up to 5 ml, it is injected intramuscularly and intravenously for doses up to 10 ml.

The price of Cerebrolysin

In the USA, the consumers have to pay an average retail price of 42.00 USD – 75.00 USD for the supply of two 20 ml ampoules. In India, 5 ampoules containing 10ml, cost around US$9. It is a relatively inexpensive medicine in the developing and underdeveloped world.

How does it work?

Cerebrolysin has a promoting effect on neurogenesis and oligodendrogenesis via stimulating the expression of the Shh signalling pathway. Cerebrolysin increases mRNA modulation of its receptors ‘Patched’ and ‘Smoothened’. Its actions promote post-stroke brain repair and functional recovery, and suggests the Shh pathway to target for prolongation of the therapeutic window after stroke. Several fragments of NTFs are capable of stimulating neurotrophic signaling pathways. Cerebrolysin shows BDNF-like activity by stimulating pathways that plays an important role in cell growth, proliferation, migration and differentiation.

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