CHLORZOXAZONE

Chlorzoxazone relieves stiffness and pain caused by muscle strains and sprains. It can be used in combination with physical therapy, analgesics, and rest. Chlorzoxazone seems to act at the spinal cord and subcortical levels of the brain. This helps it inhibit multisynaptic reflex arcs involved in producing and maintaining muscle spasms, and can also for acute pain in general and for tension headache. Chlorzoxazone is sold under the Brand names Paraflex®¶, Parafon Forte® DSC, Strifon Forte® DSC among others. Pfizer & Co file the first patent for Pharmaceutical composition and process for preparing the same in 1954. The USFDA first approve Chlorzoxazone for use in the United States in 1958 and is still widely used. It is sold in various generic forms as well as brands.

Dosage and administration:

Chlorzoxazone is sold as tablets of varying strengths. In the measures for musculoskeletal pain associated with acute musculoskeletal conditions, it is for adjunctive therapy to rest, physical therapy, and another Oral dosage. The initial adult dose is 250 to 500mg, given in 3 to 4 times per day. The usual recommended initial dose for painful musculoskeletal pains is 500 mg daily, in 3 to 4 doses. However, the older and weaker patients are given a lower dose. The recommended daily dose should not exceed 3000mg and for older patients, the maximum daily dose is 1000 mg a day. In general, patients with hepatic impairment are advised not to use this medicine or with the advice of the doctor. In the treatment of Muscle Spasm, the Usual initial Adult Dose is between 250 to 500 mg, taken orally, 3 to 4 times a day. If the standard dose does not provide, then it can be increased to 750mg.

The Price of Chlorzoxazone

In the USA, the consumer has to pay an average retail price of $49.56 for 60 tablets of generic brand of 500mg strength. In India, the tablets of 250mg in combination with Paracemtol cost USD 0.40, and the price of the MR tab of 500mg in combination with paracetamol 500mg cost around USD 0.65.

How does Chlorzoxazone work?

Chlorzoxazone’s exact mechanism of action is not yet known. However, it has been thought to act at the spinal cord and subcortical levels of the brain. This inhibits multisynaptic reflex arcs involved in producing and maintaining muscle spasms. it does this by exerting actions on Gaba-A & B receptors and voltage-gated calcium channels to a degree.

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