Clindamycin

Clindamycin is an antibiotic used for the treatment of a number of bacterial infections, including bone, joint, and pelvic inflammatory disease, many infections affecting the ear, nose, and throat region, and endocarditis. It can also be used to treat acne, dental infections, skin, and soft tissue, and peritonitis. Patients who are hypersensitive to penicillins are also given Clindamycin in the treatment of infections caused by susceptible aerobic bacteria. The topical application of clindamycin phosphate is also to manage mild to moderate acne and some cases of methicillin-resistant Staphylococcus aureus. Clindamycin is marketed as Cleocin HCl, Clindacin, Dalacin, Evoclin, and Lincocin amongst others. In 1966 Clindamycin was first extracted from lincomycin, which naturally occurs in a plant found in Alaska. It is a generic medication and on the World Health Organization's List of Essential Medicines.

Forms and Dosage

Clindamycin forms administered orally include capsules and oral suspensions. Clindamycin is a vaginal cream and vaginal ovules are used for the treatment of bacterial vaginosis. It is also sold for topical administration in gel form, as a lotion, and in a foam delivery system and a solution in ethanol and is used primarily as a prescription acne treatment. Common side effects of using Clindamycin include nausea, diarrhea, rash, and pain at the site of injection. For long term treatment of acne, the combined use of topical clindamycin and benzoyl peroxide works just like salicylic acid plus benzoyl peroxide. The common usual dose of Clindamycin is from 150 and 450mg every six-eight hours, depending on the severity of the infection. Sometimes, Doctor can also prescribe Clindamycin 600mg Capsules, the usual dose of which is one capsule every 8 hours.

The cost of Clindamycin

The wholesale cost in the developing world is US$0.06 to US$0.12 per pill whereas the same medicine in the United States it costs about $2.70 per dose and the average price consumers pay for 30 Capsules of 300mg each of the generic brands is $95.99.

How does Clindamycin work?

Clindamycin has a primarily bacteriostatic effect in that it works by slowing or stopping the growth of bacteria. Just like antibiotics, Clindamycin works by inhibiting bacterial protein synthesis thereby inhibiting bacterial growth. It also has a bacteriostatic effect in that it stops bacteria from reproducing but can’t kill them. Clindamycin’s actions work by binding to the 50s ribosomal subunit of bacteria thus disrupting protein synthesis in the process by interfering with the transpeptidation reaction, which thereby inhibits early chain elongation.

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