Daratumumab Manufacturers

Daratumumab is a monoclonal antibody belongs to a class of drugs called as monoclonal antibodies. This medication is used to treat multiple myeloma (bone marrow cancer). Daratumumab is usually given when treatment with other drugs have failed. This drug is sometimes used in combination with other cancer medicines along with a steroid. This medication is advised as a prescription product as well as mixture product. Daratumumab is marketed by manufacturers under the Brand name of Darzalex. It is issued only on physician’s prescription. This drug is available in the dosage form of Injection which is administered intravenously. There is no pill form of daratumumab. The available dosage strength of daratumumab is 20 mg / ml, 100 mg / 5 mL, 400 mg / 20 mL solution. This injection / vial is for single use only and should be administered by a healthcare professional. Daratumumab is a prescription medicine and used to treat adult patients with multiple myeloma, this medication is not recommended in children as safety and efficacy is not established. This drug is indicated as a monotherapy for multiple myeloma in patients who have received at least 3 lines of therapy. The recommended dose is 16 mg / kg I.V. infusion weekly once for a total of 8 doses for a period of eight weeks, and 16 mg / kg I.V. infusion every 2 weeks for a total of 8 doses from week 9 – 24. The first dose of every-2-week dosing schedule is given at week 9. And from week 25 onwards until progression of disease 16 mg / kg I.V. infusion every 4 weeks, the first dose of every-4-week dosing schedule is given at week 25. Daratumumab is also used as a combination drug, the dosing schedule of daratumumab with combination therapy of lenalidomide and low dose dexamethasone and a combination therapy of pomalidomide and low dose dexamethasone is same as that of the monotherapy of daratumumab. Daratumumab is recommended to store in a refrigerator at 2° C - 8° C (36° F - 46° F) away from light. Do not shake and freeze.

Wholesale Price of Daratumumab

The wholesale price of 20 mg/mL Daratumumab intravenous solution is around $ 589.63 for a supply of 5 milliliters with per unit cost at $ 117.93, and the cost for 20 milliliters is priced at $ 2,330.02 with unit price available at as low as $ 116.50 depending up on the pharmacy one visit.

Daratumumab - Mechanism of Action

Daratumumab is a targeted therapy that targets CD38. CD38 is a transmembrane glycoprotein, expressed on the surface of hematopoietic cells including myeloma cells. When daratumumab binds to CD38, it inhibits the growth of CD38 expressing cancer cell and generate rapid tumor cell death directly through mediated cross linking as well as by immune mediated tumor cell lysis through complement dependent cytotoxicity, antibody dependent cellular phagocytosis and antibody dependent cell mediated cytotoxicity. As a result, daratumumab works by slowing or stopping the growth of cancer cells.

Finding Daratumumab Manufacturers and Suppliers

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