Dexketoprofen Trometamol

Dexketoprofen trometamol is the formulated tromethamine salt of the NSAID Ketoprofen. Dexketoprofen trometamol is recommended to treat mild-to-moderate pain conditions such as musculoskeletal pain including osteoarthritis, low back pain, dental pain and dysmenorrhea It is used as an analgesic and anti-inflammatory drug. The parenteral formulation is indicated for the symptomatic treatment of acute pain of moderate-to-severe intensity, when oral administration is not appropriate, such as for postoperative pain, renal colic and low back pain. Dexketoprofen trometamol is sold under the trade name Keral. Menarini Lab created this in search of a novel aryl propionic derivative. They created a process for the preparation and the use thereof as an analgesic agent in 1993 and were granted the patent in 1995. It is a prescription medicine available in the UK.

Forms and dosage

Dexketoprofen trometamol is sold in the forms of oral tablets, solution or granules, and parenteral formulation for injections. The usual adult recommended dose starts at 12.5 mg, taken every 4 to 6 hours or 25 mg to be taken every 8 hours. The daily intake of this medicine should not exceed 75 mg when administering orally or 50 mg every 8 to 12 hours or every 6 hours if necessary. In all the cases the daily maximum dose cannot exceed 150 mg for the parenteral formulation.

The price of Dexketoprofen Trometamol

The wholesale price of the ingredient version of this peptide is between US$200 and USD 235 in the developing world, including Asia and Africa. In the Philippines, 1 tablet containing 25mg of Dexketoprofen Trometamol costs around US$0.66 per pill.

How does it work?

Dexketoprofen trometamol actions inhibit cyclooxygenases 1 and 2. Dexketoprofen trometamol is equal to double dose of the racemic mixture and other NSAIDs but with a faster onset of analgesia probably due to the tromethamine salt formulation. The main mechanism of action of dexketoprofen, like other NSAIDs, is the inhibition of cyclooxygenases (COX), enzymes responsible for the synthesis of prostaglandins. In the racemic mixture of ketoprofen, this effect is mostly due to ketoprofen. Dexketoprofen is an anti-inflammatory and antipyretic drug that shows the analgesic effect lasting for 4–6 hours and reported analgesic activity within 30 min post-administration.

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