Disulfiram is a carbamate derivative used as an alcohol deterrent. It is a member of the drug used in alcohol dependence drug class and is commonly used for alcohol dependence. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. Disulfiram is used for treating alcoholism with potential antineoplastic and chemo sensitizing activities. Disulfiram is advised as a prescription product, generic prescription product as well as the mixture product. Disulfiram is marketed by manufacturers under the brand name of Antabuse. This drug is available only with the doctor’s prescription and is available in the dosage form of Tablet which is administered orally once a day. The tablet form is available in a dosage strength of 250 mg and 500 mg. The recommended initial dose in adults for alcohol dependence is 500 mg orally once a day which is generally continued for the first 1 to 2 weeks, then after two weeks a maintenance dose of 125 to 500 mg orally once a day is given with the average maintenance dose 250 mg daily. The maximum dose is 500 mg once a day with the duration of therapy lasts for months or even years depending on the individual. This medication is preferably administered in the morning, however in patients who experience sedation, it may be given at bedtime. The drug is not recommended for patients younger than 18 years as safety and efficacy have not been established. Disulfiram should never be administered to a patient when they are in a state of alcohol intoxication or without the patient's full knowledge. The drug should be stored at room temperature 20° C to 25° C (68° F - 77° F). Wholesale Price of Disulfiram The price of Disulfiram 250 mg oral tablet is around $ 54.90 for 30 tablets with a per unit cost of $ 1.83. For a set of 100 Disulfiram 250 mg oral tablets it costs around $160.82 with a per unit price as low as $ 1.61 The wholesale price of 500 mg Disulfiram oral tablet for a set of 100 tablets costs around $ 312.30 with per unit cost comes at $ 3.12 and for a set of 30 tablets it costs approximately $ 100, with per unit cost $ 3.34 Disulfiram - Mechanism of Action Disulfiram is used for treating alcoholism. Alcohol is converted in the body into acetaldehyde by an enzyme called alcohol dehydrogenase. Another enzyme called acetaldehyde dehydrogenase then converts acetaldehyde into acetic acid. Disulfiram prevents acetaldehyde dehydrogenase from converting acetaldehyde into acetic acid, leading to a buildup of acetaldehyde levels in the blood. High acetaldehyde levels cause unpleasant symptoms after drinking alcohol such as palpitations, low blood pressure, chest pain, nausea, vertigo, headache and flushing etc., these unpleasant side effects dissuade alcoholics from drinking. In addition to its effect on acetaldehyde dehydrogenase, disulfiram inhibits other enzyme systems including dopamine-beta-hydroxylase (which converts dopamine and noradrenaline) and hepatic microsomal mixed function oxidases (which are responsible for the metabolism of many drugs). Disulfiram may thus potentiate the action of drugs which are metabolized by these enzymes. Finding Disulfiram Manufacturers and Suppliers Finding a faithful partner in our business is one of the massive tests and to defeat that challenge and to make one’s work and life easy in finding the credible manufacturer and supplier of Disulfiram, one can visit the Pipelinepharma website which helps you in finding the dependable manufacturers and suppliers of Disulfiram. Pipelinepharma, which is a business-to-business (B2B) licensing marketplace for pharmaceutical products, quickly connects proprietor with the consumers for the business development. You can filter the product names in user familiar and unified search engine by its country, category, therapeutic area, forms, dossier and its status, regulatory filings, approvals, and more.