Erdosteine
Erdosteine is used as a mucolytic and fluidifying agent sued to treat acute and chronic affections of the upper and lower respiratory tract especially in cases of mucus hyper-secretion. Erdosteine controls the viscosity of the sputum in infections, resulting in more fluid and less thick sputum. The actions increase of mucociliary rate allowing for easy mucus removal from the respiratory tract. Erdosteine is highly effective in relieving symptoms of Chronic Obstructive Pulmonary Disorder.
Erdosteine reduces both the duration and frequency of symptomatic exacerbations. The Global Initiative for Chronic Obstructive Lung Disease, International Guidelines indicate that regular treatment with a mucolytic like erdosteine can reduce exacerbations and improve the health status of patients with COPD. In some countries, Erdosteine is approved for the treatment of bronchiectasis.
Erdosteine is sold under the commercial names Esteclin and Erdotin amongst others.
Recipharm in Italy discovered and developed Erdosteine in 2017. It has been listed in the 2019 GOLD report, the global standard for COPD medications.
Forms and dosage:
Erdosteine is available as hard capsules of 300 mg, dispersible tablets of 300 mg, granulates for oral suspension 225 mg, and powder for oral suspension 175 mg/5ml concentrations respectively.
The recommended usual adult dose for elderly patients and adults above 18 years is one capsule of 300 mg, taken twice a day, with the course lasting 10 days.
The price of Erdosteine
In the USA, the consumers have to pay around USD1.28 for 10 tablets of 300 mg. whereas, in the United Kingdom, the price of 10 tablets of 300 mg is approximately USD25. The price of this medicine is cheaper in developing and underdeveloped countries.
How does Erdosteine work?
Erdosteine’s molecule drives a mucolytic activity, which is a thiol derivative with the presence of two thiol groups. These groups in the Erdosteine’s molecule are released in the conversion of erdosteine into its active metabolite Met-I after the first-pass metabolism. Its molecule is an oral mucoactive anti-oxidant molecule, with a multi-faceted pharmacological profile that positively interferes with several pathological processes in respiratory disorders which have thickened or increased mucus production resulting in increased oxidative stress, and chronic inflammation.
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