Fenticonazole

Fenticonazole is an imidazole antifungal drug. It is for local use in its nitrate form in the treatment of vulvovaginal candidiasis. It has been effective in curing a range of fungal organisms including dermatophyte pathogens, Malassezia furfur, and Candida albicans. Fenticonazole kills the yeast fungus causing the infection. An occasional bout of vaginal thrush is an issue many women have caused Candida spp caused the infection. Thrush is caused by Candida albicans but other types of Candida spp. Have been known to cause thrush. During the Thrush, the woman feels itching, soreness, and redness outside of the vagina in addition to a thick, creamy white, odorless vaginal discharge. Fenticonazole is sold under the brand name Fentizol, Ginna, and Lomexin amongst others. Fenticonazole is not for sale in the USA and was sold only on prescriptions in the UK, however, it is not sold in the EU anymore. A Chinese co is the current assignee of the EU agent since 2012. In 2020. Glenmark also released its brand in India.

Dosage and administration

Fenticonazole is sold as a pessary, topical cream, solution, and a vaginal capsule. The regular treatment includes inserting a 200 mg pessary the vagina at bedtime for 3 nights. Or they can also use a single 600 mg pessary is inserted once. When used topically, it used as a 2% cream or solution. If using a vaginal capsule, the user has to gently insert it, as high as possible using a finger into the vagina at bedtime. The doctor will decide if the user needs it for three days or one and do remember not to swallow this medicine. When using the cream, it is used twice a day, morning and the evening, for three days. The user is sold the applicator with the cream. Using this applicator, the user inserts 5 grams of cream high into her vagina. Use the applicator, after squeeze cream into it until it is full. After removing the applicator from the tube once it is full the user then has to gently insert the cream-filled end of the applicator into the vagina as high as it is comfortable. Once the inserter as high as it goes, the user Pushes the plunger to release the cream. After this, the user has to remove the applicator and wash it with warm water and soap.

The Cost of Fenticonazole

In India, the consumers have to pay USD 2 for 2% Cream, whereas 1 vaginal capsule with 600mg medicine costs USD 2. In the ingredients market, the wholesale cost of 1kg is USD 377. Fenticonazole is not for sale in the US, while it was sold in the UK, it has now been withdrawn.

How does Fenticonazole Work?

Fenticonazole has unique antimycotic actions. The show effect in these three ways, first by inhibiting the secretion of protease acid by Candida albicans, then it goes on to damage to the cytoplasmic membrane and it also blocks cytochrome oxidases and peroxidizes. These three combined actions cause fungicide.

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References

https://patient.info/medicine/fenticonazole-for-vaginal-thrush-gynoxin https://en.wikipedia.org/wiki/Fenticonazole https://www.indiamart.com/proddetail/fenticonaz-cream-fenticonazole-2- 20942665962.html#:~:text=Fenticonazole%202%25%20Healing%20Pharma%20Fenticonaz, 135.00%20%2Funit%20%7C%20ID%3A%2020942665962