Hydroxyprogesterone caproate

Hydroxyprogesterone caproate is a man-made progestin hormone. It helps lower the risk of giving birth too early, which is preterm birth or giving birth less than 37 weeks of pregnancy in pregnant women. Only pregnant women who are pregnant with one baby and with preterm delivery of one baby in the past have prescribed this medicine. It is used with mothers who have had a history of gynecological disorders. Hydroxyprogesterone is progestin hormones that reduce the risk of premature birth through a mechanism that is yet to be fully explained. In combination with other estrogens, it is also used as an injectable form of long term birth control.  Hydroxyprogesterone caproate is sold under the brand names Proluton and Makena among others. After the expiry of its original patent, this product has been made and distributed by companies around the world with ever-newer formulations to increase the conditions it can help treat. Schering AG developed OHPC in 1953. It was first reported in the medical literature in 1954. First marketed only in Japan in 1954 or 1955, it was subsequently introduced as Delalutin in the United States in 1956. However, the manufacturer Squibb withdrew its patent in 1999, post which it was also discontinued in the USA. But it was reintroduced in the United States under the brand name Makena for the treatment of preterm birth in 2011. 

Forms and Dosage:

Hydroxyprogesterone caproate is available alone in the form of ampoules and vials of 125 and 250 mg/mL oil solutions for intramuscular injection and a 250 mg/mL autoinjector for use by subcutaneous injection. In lowering the risk of Premature Labor, the Usual Adult Dose is given between 16 weeks, 0 days and 20 weeks, 6 days of gestation, is 250 mg, administered intramuscularly once every 7 days in the upper outer quadrant of the gluteus maximus. When the injection is administered subcutaneously, the usual adult dose is 275 mg once every 7 days in the upper arm.

The price of Hydroxyprogesterone Caproate

In the USA, consumers have to pay around $2,311.19 for 5ml of 500mg Injection or around $419 for a supply of 1 milliliter (s). The price of this medicine is significantly cheaper in the developing or underdeveloped world. For example, the price of 2ml f this medicine costs only USD 2.5 to USD4. Hydroxyprogesterone Caproate was earlier sold at low prices by compounding pharmacies in the USA, but this became prohibited in 2016.

How does it work?

Hydroxyprogesterone belongs to a group of drugs called progestin hormones. These work to reduce the risk of premature birth through a mechanism that is currently not yet fully understood.

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