Isosorbide Dinitrate is sold under the brand names Isordil, Dilatrate, and Bidil. It belongs to the Nitrate class of drugs. It is used to treat heart failure, esophageal spasms, and chest pain from not enough blood flow to the heart. It is mostly taken in combination with Hydralazine. It is available in strengths of 2.5mg, 5mg, 10mg, 20mg, 30mg, 40mg and 50mg. It is commonly administered through the oral route of drug administration. It is metabolized by the liver and is excreted by the kidney in urine. Its elimination half-life is approximately one hour. This pharmaceutical medicine interacts with certain drugs which include drugs used to treat erectile dysfunction such as Sildenafil, Tadalafil, and drugs used to treat migraine headaches such as Ergotamine. Side effects related to this pharmaceutical medicine include headache, lightheadedness with standing, blurred vision, postural hypotension, and plasma volume expansion. It is contraindicated in conditions like significant anemia, methemoglobinemia, hypertrophic cardiomyopathy, and high pressure within the skull. The FDA placed it in category C of drugs used in pregnancy and should be used with the physician’s recommendation. Its secretion into human milk is not known. It was approved by the FDA on June 23, 2005, under the brand name Bidil, manufactured by the NitroMed company.

It works by relaxing vascular smooth muscles and dilatation of peripheral arteries and veins.

Cost of 50 tablets of Isosorbide Dinitrate 10mg is 44 dollars approximately.

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