L-ornithine L-aspartate is a medicine for people with advanced liver disease with reduced brain function. Research conducted on L-ornithine-L-aspartate efficacy showed that it can reduce symptoms of reducing brain function in people with a liver disease called cirrhosis. However, L-ornithine-L-aspartate might not help control symptoms hepatic encephalopathy, which were caused by some other reason. L-ornithine-L-aspartate also helps improve athletic performance. L-ornithine-L-aspartate is a combination of two amino acids, ornithine and aspartic acid. While the body uses amino acids as building blocks to make protein, L-ornithine L-aspartate is not used to make protein. The human body instead brakes it down in to get ornithine and aspartic acid. Merz pharma in Germany first filed for a patent and was granted around 2010. Evonik industries and some Japanese companies have also filed for patents for different preparations of these medicines. Most frequently prescribed for impaired brain function in adults with severe liver disease (hepatic encephalopathy). There isn't any solid scientific data to back up its usage for cirrhosis, enhancing athletic performance, or any other conditions. According to research, administering L-ornithine-L-aspartate orally or intravenously to cirrhotic patients may lower their risk of passing away. However, not all studies concur. To determine whether L-ornithine-L-aspartate can benefit those who have cirrhosis, more research is required. If administered intravenously, L-ornithine-L-aspartate is possibly safe. Some patients receiving injections of L-ornithine-L-aspartate have experienced nausea, vomiting, coughing, muscle cramps, and diarrhoea. But these adverse consequences are uncommon.

L-ornithine L-aspartate is sold in several forms like rapid melt granules, tablets and injection. In patients with advanced liver disease, the recommended daily dose for tablets is 9-18 grams for up to 3 months. Injection for the same comes with a recommended adult dose of 5-40 grams for up to 7 days.

LOLA is what is known as a stable salt of the two constituent amino acids, L-ornithine and L-aspartate. L-ornithine stimulates the urea cycle finally resulting in loss of ammonia. L-ornithine L-aspartate actions lower blood ammonia levels and increase the levels of ornithine and aspartic acid in the body. Ammonia is then used to convert glutamate to glutamine by glutamine synthetase. As both a l-ornithine and l-aspartate are both substrates for glutamate transaminase, LOLA administration can result in increased glutamate levels. Ornithine and aspartic acid levels in the body are raised by L-ornithine L-aspartate. These amino acids aid in lowering blood levels of the poisonous toxin ammonia.

An online search for the wholesale price for sale of L-ornithine L-aspartate for distributors will reveal a wide range of costs. It will vary from store to store depending on your visit and the country of the wholesale market. The consumer in the USA has to pay USD 70 for a supply of 100g of L-ornithine-L-aspartate. The cost of this medicine varies widely in the developing world, as can be seen in India, where the same supply of 100g will cost between $7-$70.

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