Methenamine Hippurate Manufacturers

Methenamine belongs to the family of drugs called anti-infectives. The main use of methenamine is an antibiotic, which eliminates bacteria that cause urinary tract infections. Methenamine is usually used on a long-term basis for the treatment of chronic infections and to prevent the recurrence of infections. Antibiotics may not work for colds, flu, and for other viral infections. This antibiotic is effective only against bacterial infections which are mainly seen in the urinary tract. Methenamine works better if your urine is more acidic. Physicians take the acidity of your urine (urine pH). If necessary, take the recommended ways to increase urine acidity (such as by taking vitamin C/drinking cranberry juice, limiting foods that decrease acidity/increase alkalinity such as milk products/most fruits, adjusting alkalizing medications). Methenamine hippurate is indicated for the prophylactic or suppressive treatment of frequently recurring urinary tract infections when long-term therapy is considered necessary. This drug should only be used after the eradication of the infection by other appropriate antimicrobial agents. Methenamine is marketed with the name of Brand Name Urex, Hiprex Adverse effects of methenamine hippurate have been reported in fewer than 3.5% of patients treated. These reactions have included the following, in decreasing order of frequency: nausea, vomiting, and Rarely pruritus, rash, dysuria. Children who have received methenamine hippurate at the recommended dosages as a prophylactic/suppressive regimen after initial treatment of acute episodes of pyuria. Side effects were encountered in only 1.1% of these children. 1 tablet (1.0 g) twice daily in the morning and in the night for adults and for pediatric patients over 12 years of age must be consumed in - 1/2 to 1 tablet (0.5 to 1.0 g) twice daily in the morning and in the night for pediatric patients 6 to 12 years of age. This drug is Supplied in a 1-gram scored; capsule-shaped yellow tablet debossed in bottles of 100. Methenamine comes as a tablet and a liquid to take by mouth. It usually is taken either two times a day (every 12 hours) or four times a day (after meals and at bedtime). Methenamine Hippurate is to be stored at a temperature of 20° C to 25° C (68° F - 77° F).

Wholesale Price of Methenamine Hippurate

The cost for methenamine oral tablet mandelate 0.5 g is around $72 for a supply of 100 tablets, The cost for methenamine oral tablet mandelate 1 g is around $81.64 for a supply of 50 tablets

Methenamine Hippurate - Mechanism of action

Methenamine Hippurate is the salt form of methenamine, a prodrug and inactive weak base that slowly hydrolyses the nature of the acidic urine to ammonia and the effective, urinary tract antiseptic formaldehyde. Formaldehyde probably exerts its antibacterial effect by denaturation of protein. Depending on the urinary concentrations, formaldehyde is either bactericidal or bacteriostatic. Formaldehyde urinary concentrations are dependent on urine pH, volume, and flow rate of the produced enzymes which are initiated with being the administration of the Methenamine.

Finding Methenamine Hippurate Manufacturers and Suppliers

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