Metolazone

Metolazone is a medication called ‘water pills’, belonging to a type of drugs called diuretics, primarily used to treat congestive heart failure and high blood pressure. Lowering high blood pressure helps in the prevention of serious heart and kidney problems. Metolazone helps in reducing the swelling and fluid retention in cases patients with heart failure and or kidney disease. Metolazone makes kidneys decrease the amount of water and salt it stores body by increasing the amount of urine, as in its primary action while treating kidney problems is make the body produce more urine to order expel the excess fluids. Metolazone is frequently a part of larger combination of therapy. Metolazone is marketed under the brand names Zytanix, Metoz, Zaroxolyn, and Mykrox to name a few. Metolazone was first patented in 1966 and later developed in the 1970s, by an Indian born chemist Dr. Bola Vithal Shetty. Metolazone gained popularity it causes little kidney toxicity compared to other diuretics. It has been approved for medical use since 1974.

Forms and Dosage

Metolazone is sold as tablets in the increasing strength of 2.5mg, 5mg, and 10mg tablets. For the treatment of edema in congestive heart failure or kidney disease, a dose of 5-20mg once daily, as the initial treatment. The dosage is adjusted as per the response of the body. In the treatment of high blood pressure, the patients are administered 2.5-10 mg once a day. Metolazone should not be taken at the start of the day or activity, because it takes some time for its absorption and duration of action.

The Cost of Metolazone

The cost of 30 tablets of 5 mg strength will cost the consumer a retail price of USD65 on a average, it is as low as USD56 and as high as USD75 based on the brand and pharmacy in the USA. In the UK, the same supply from the generic drug maker cost upwards of 15 pounds. How does Metolazone work? Metolazone works by increasing the amount of urine body makes, in the process making the body get rid of excess fluids/liquids through the urine. Metolazone indirectly decreases the amount of water getting reabsorbed into the bloodstream through the kidney, there by decreasing the blood volume and increasing the urine volume. As the body expels the salts in urine, it helps lowering the blood pressure and preventing excess fluid accumulation during heart failure.

Finding Metolazone Manufacturers and Metolazone Suppliers

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