MICAFUNGIN SODIUM

Micafungin is the sodium salt form of Micafungin. It is an antifungal medicine, as it treat and prevent invasive fungal infections. These include candidemia, abscesses and esophageal candidiasis. It works by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall. The infection treated by include Candidemia and Other Invasive Candida Infections, Esophageal Candidiasis, Oropharyngeal Candidiasis, Candida auris Infections, Prevention of Candida Infections in Hematopoietic Stem Cell Transplant Recipients and Aspergillosis. Micafungin Sodium is sold under the brand name Mycamine. Micafungin Sodium received final approval from the U.S. FDA in 2005, and gained approval in the European Union in 2008. Since 2008, Micafungin was also approved for the prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation.

Dosage Forms & Strengths

Micafungin Sodium is sold as Powder for injection if 50mg/vial, 100mg/via doses. In the treatment of esophageal Candidiasis, the usual adult dose is 150 mg per day for two weeks. In the Prophylaxis in hematopoietic stem cell transfer patients, the recommended does is 50 mg a day for nearly 3 weeks. In the treatment of Candidemia, Disseminated Candidiasis, Candida Peritonitis & Abscesses, the patient is given 100 mg a day for two weeks.

The price of Micafungin Sodium:

In the USA, for a single 50mg vial, the consumers have to pay an average retail price of USD 171. In the UK, this price of the same is at 196.08, where as India, the price for the same supply in India is around US$85.

How doe Micafungin Sodium work?

Micafungin, like any cyclic lipopeptides drug, inhibits the fungal specific enzyme 1,3-beta-D- glucan synthase noncompetitively. This enzyme is essential in synthesis of the important fungal cell wall component 1,3-beta-D-glucan. Its actions prevent this synthesis of 1,3-beta- D-glucan, as a result the cell wall is weakened, eventually leading to osmotic lysis and eventually fungal cell death.

Finding Manufacturers and Suppliers:

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