Morphine Sulfate is sold under the brand name “Roxanol”, and is classified as an Opioid agonist. It is used in relieving moderate to severe acute and chronic pain. It is available in 20mg/ml solution and is administered through the oral route. Its usual adult dose is about 10 to 30mg every 4 hours and can be increased to achieve the desired level of analgesia. It is 90 percent metabolized by glucuronidation in the liver and 70 to 80 percent is excreted in 48 hours. Drug interactions can occur when this pharmaceutical medicine is used simultaneously with other CNS depressants such as sedatives, hypnotics, tranquilizers, general anesthetics, and phenothiazines can increase the risk of respiratory depression. Side effects associated with this pharmaceutical medicine are slow heart rate, shallow breathing, hallucinations, chest pain, muscle stiffness, twitching, loss of coordination, mood changes, and stomach problems. It also causes withdrawal syndrome on discontinuation. It is contraindicated in conditions like an acute or severe bronchial spasm and paralytic ileus. It is categorized in pregnancy category C drugs. It can cross the placental barrier and if administered during labor can result in respiratory depression in the neonate. It is excreted in human milk hence precautions should be taken in nursing mothers. It was approved by the FDA on May 18, 2004, under the brand name DepoDur, manufactured by Skye Pharma Inc.

It binds to the opioid receptors and blocks the transmission of pain signals. It has an onset time of 6 to 30 minutes.

60 tablets of Morphine Sulfate extended-release 15mg cost around 66.59 dollars.

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