Nalbuphine Manufacturers

Nalbuphine is an opioid pain medication that belongs to a class of drugs called narcotic. It is used to treat moderate to severe pain. It is also used for treating pain just after surgery or childbirth. Nalbuphine hydrochloride is a synthetic opioid agonist-antagonist analgesic of the phenanthrene series. Nalbuphine is chemically related to both the widely used opioid antagonist, naloxone, and also the potent opioid analgesic, oxymorphone. Opioid pain relievers are medicines that can help manage pain when other treatments and medicines are not able to provide enough pain relief. Certain opioids are also used to treat OUD. Naloxone can help reverse opioid overdose to prevent death. Nalbuphine Injection is a sterile, nonpyrogenic solution of nalbuphine hydrochloride in water for injection. This product may be administered by subcutaneous, intramuscular, or intravenous injection injectable solution 10mg/mL, 20mg/mL Before using this medication, the risk of taking the drug must be weighed against the benefits it provides. It is always recommended to consult a physician before taking Nalbuphine as this medication may interact with other drugs and health problems. This drug is indicated for the management of pain that is severe enough to require an opioid analgesic and for which alternative treatments are inadequate which have not provided any results.. Nalbuphine can also be used as a supplement to be balanced anesthesia, for preoperative and postoperative analgesia, and for obstetrical analgesia during labor and delivery. Marketed with Brand name Nubain. The usual Adult dose of Nalbuphine is 10 mg for 70 kg which is administered subcutaneously, intramuscularly, or intravenously; this dose may be repeated every 3 to 6 hours, as necessary. Store at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F). Common side effects with Nalbuphine are Nervousness, depression, restlessness, crying, euphoria, floating, hostility, unusual dreams, confusion, faintness, hallucinations, dysphoria, feeling of heaviness, numbness, tingling, unreality. Nalbuphine may interact with other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or any other medicines that can make you sleepy or slow your breathing.

Wholesale Price of Nalbuphine

In the USA, the wholesale price of 10 mg/mL nalbuphine injectable solution ranges from $ 39.81 - $ 40.08 for a quantity of 10 milliliters and the per-unit cost is available at as low as $ 3.98 The per-unit cost of 20 mg/ml nalbuphine injectable solution comes at $ 62.07 for a quantity of 10 milliliters with the per-unit cost is available at as low as $ 6.21

Nalbuphine - Mechanism of action

Nalbuphine interacts with an opiate receptor site in the CNS (probably in or associated with the limbic system). The opiate antagonistic effect may result from competitive inhibition at the opiate receptor but may also be a result of other mechanisms. Primarily nalbuphine is thought to be a kappa agonist. Nalbuphine also acts as a partial antagonist analgesic, with some binding properties to the delta receptor and minimal agonist activity at the sigma receptor. Absorption percentage 81% and 83% for the 10 and 20 mg intramuscular doses, respectively, and 79% and 76% following 10 and 20 mg of subcutaneous nalbuphine polycyclic compounds containing a phenanthrene moiety, which is a tricyclic aromatic compound with three non-linearly fused benzene.

Finding Nalbuphine Manufacturers and Suppliers

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