Naproxen sodium is the sodium salt of naproxen - a medication that belongs to the nonsteroidal anti-inflammatory drug class and is used to treat a wide range of pain indications, particularly in cases of inflammatory conditions such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. The salt form does not differ from the base form in terms of mechanism of action, albeit it dissolves more quickly, leading to a quicker onset of effect. Moreover, it is slightly less potent (i.e. 220, 275, or 550 mg of naproxen sodium is equivalent in potency to 200, 250, and 500 mg of base naproxen). Although manufacturing companies typically market naproxen sodium as a standalone drug, it is also used in combination drug formulations, along with other active ingredients such as paracetamol, esomeprazole, omeprazole, among others. Naproxen was first approved for medical use by the FDA in 1976, and has since then become approved in and supplied to numerous countries worldwide. In the USA alone more than 11 million subscriptions for the drug are registered yearly.

Naproxen, like some other non-selective NSAIDs, works by inhibiting COX-1 and COX-2 catalysts, resulting in a reduction in prostaglandin formation. Even though both catalysts play a role in prostaglandin synthesis, they have distinct functional distinctions. The COX-1 enzyme is located in healthy tissue such as the gastrointestinal lining and is due to the activation, but the COX-2 enzyme is upregulated and creates prostaglandins which regulate pain, fever, and irritation. The COX-2 enzyme is responsible for Naproxen's beneficial antipyretic, analgesia, and generally pro characteristics, whereas the COX-1 enzyme is responsible for unwanted side effects include gastrointestinal discomfort and kidney toxicity. Since naproxen is a powerful painkiller, it can cause unwanted side effects in patients. Naproxen, for example, can hurt blood pressure regulation. A study discovered that using naproxen caused a rise in blood pressure, though it's not as severe as taking ibuprofen. Furthermore, studies have shown that people who take NSAIDs have a four-fold increased risk of upper gastrointestinal bleeding. Simultaneous use of steroids or blood thinners, as well as a history of gastrointestinal ulcers, are other variables that enhance the risk of disseminated intravascular coagulation.

Naproxen is available for sale from a variety of Naproxen vendors at a range of costs. Prices are only valid for consumers who pay cash and do not apply to insurance coverage. Naproxen suppliers, on the whole, are in favor of patient aid initiatives. Wholesale prices per 20 550mg naproxen sodium tablets fall into an approximate range of $5.00 to $7.00, whereas the same amount of 275mg tablets may cost anywhere from $4.00 to $5.00. This cost may differ among dealers. Its cost varies depending on the country of origin, manufacturing businesses' wholesale expenses, supplier pricing, and other considerations. Patient assistance programs, which provide free or subsidized drugs to low-income, unemployed, or under-insured patients who meet certain criteria, are often supported by pharmaceutical companies.

Bayer, AstraZeneca, and Teva are among the leading manufacturers and suppliers in the global naproxen sodium market. Both generic and brand-name versions of naproxen sodium are available. Buyers should be aware that online sellers may try to sell counterfeit versions of generic drugs, whereas Pipeline Pharma ensures that only verified manufacturers and wholesalers enter our online marketplace through pre-auditing and quality control procedures, providing you with a risk-free B2B pharmaceutical sales platform. Other NSAID class medications, such as ibuprofen, diclofenac, meloxicam, or celecoxib, are the principal alternatives to naproxen sodium.

Being a global B2B pharmaceutical online marketplace, Pipelinepharma is structured to simplify pharmaceutical deals by providing you with an intuitive interface that is easy to engage with. The selection of Naproxen offerings can be narrowed down with the use of filters and easily weighed against one another according to medication prices and commercial terms. The advanced filters help you filter out the countries for Naproxen Sodium manufacturers and Naproxen Sodium suppliers that you are looking for. These also enable you to check the dossier status of Naproxen, and the GMP approvals of the different variants of Naproxen. Also, each manufacturer or supplier product description contains essential information about Naproxen including clinical data, stability zones, countries where Naproxen is already registered in. Manufacturers also have special, and delivery terms.

If you are a pharmaceutical licensing company or a distributor you can enter into deals or negotiations over Naproxen offers with manufacturing companies after completing the free registration process and joining our online marketplace. This helps to ensure that you conclude the pharmaceutical deal at a reasonable cost and achieve the best cost/benefit ratio for your company while bypassing lengthy sourcing, negotiation, and order process. Once you have finalized a deal, you can look forward to a long-lasting business relationship with the manufacturers or suppliers. This way, the marketplace allows you as a distributor to skip the process of making a list of product manufacturers every time you are looking for in-licensing or distribution deals.

To keep up to the quality standards other than the Good Manufacturing Practice approvals that Naproxen Sodium Manufacturers list has, we qualify their companies before they are boarded on the platform. This allows us to screen Naproxen manufacturers for the quality of the pharmaceutical products’ dossiers and protect against the risk of possible malpractices.