Nifedipine is a drug that is used to reduce angina (chest pain) and treat excessive blood pressure. Nifedipine is a drug where calcium-channel blockers reduce blood pressure by relaxing blood arteries, allowing the heart to pump more efficiently. It alleviates chest discomfort by boosting the heart's oxygen and blood supply. Before starting it, notify your doctor if you have kidney or liver disease, a blockage in your digestive tract (stomach or intestines), a history of stomach surgery, coronary artery disease, an underactive thyroid, diabetes, or congestive heart failure. It is contraindicated in porphyria, myasthenia gravis, hardened liver and low blood pressure. Nifedipine is sold under the brand name Adalat and Procardia among others and is classified as Calcium channel blockers(dihydropyridine). The pharmacokinetic data of this pharmaceutical medication reveals its bioavailability as 45-56%, protein binding as 92-98% and elimination half -life as 2 hours. It is metabolized in the liver and gastrointestinal tract. It is excreted less than 50% through kidneys and 5-15% through biliary system. It is administered through oral route and is available in fast and slow-release formulations, and through tropical route. It is available as 20 mg, 30 mg, 60 mg and 90 mg. Side effects associated with this pharmaceutical medicine include lightheadedness, headache, feeling tired, leg swelling, cough, shortness of breath and heart failure. One of the serious and common side effects is postural hypotension which can lead to heart failure. It is evidenced to be safe for use in pregnancy but its use during breastfeeding is not recommended at all. Doctors advise to not take grapefruit juice while on this drug regimen and to stop taking this juice three days prior to starting the regimen. This pharmaceutical medicine is known to interact with Cimetidine, Rifampin, Carbamazepine, Phenytoin and Mitotane. If a dose is missed and time for the next dose is near then do not take a double dose to catch up rather skip the missed dose. Overdose adverse effects include lethargy, bradycardia, marked hypotension and loss of consciousness. FDA approved Nifedipine extended-release tablets on December 17, 1999, manufactured by the company Mylan Pharmaceuticals, Inc. This drug is included in WHO essential drug list and is regularly prescribed to the patients having related diseases.

In vascular smooth muscle and cardiac cells, this medicine inhibits voltage-gated L-type calcium channels. During depolarization, this obstruction inhibits calcium ions from entering cells, lowering peripheral artery vascular resistance and dilation of coronary arteries. Angina is relieved by lowering blood pressure and increasing oxygen supply to the heart. It comes with various brand names such as Procardia, Afeditab CR, Nifediac CC, Procardia XL, Adalat CC, Nifedical XL, Adalat. It is available as a capsule and as a long-acting (extended-release) tablet for oral use. Three or four times a day is the average dosage. The extended-release pill should be taken on an empty stomach once per day, either 1 hour before or 2 hours after a meal. Take it at roughly the same time every day to help you remember to take it.

Nifedipine is most commonly obtained from the pharmaceutical industry. Depending on the drugstore you visit, nifedipine oral capsule 10 mg costs roughly $10 for a supply of one capsule. Prices are only valid for cash paying consumers and do not apply to insurance programmes. In reality, the price varies according to the region where the order was made.

Being a global B2B pharmaceutical online marketplace, Pipelinepharma is structured to simplify pharmaceutical deals by providing you with an intuitive interface that is easy to engage with. The selection of Nifedipine offerings can be narrowed down with the use of filters and easily weighed against one another according to medication prices and commercial terms. The advanced filters help you filter out the countries for this substance manufacturers and this substance suppliers that you are looking for. These also enable you to check the dossier status of this medicine, and the GMP approvals of the different variants of Nifedipine. Also, each manufacturer or supplier product description contains essential information about this substance including clinical data, stability zones, countries where Nifedipine is already registered in. Manufacturers also have special, and delivery terms.

If you are a pharmaceutical licensing company or a distributor you can enter into deals or negotiations over this medicine offer with manufacturing companies after completing the free registration process and joining our online marketplace. This helps to ensure that you conclude the pharmaceutical deal at a reasonable cost and achieve the best cost/benefit ratio for your company while bypassing lengthy sourcing, negotiation, and ordering process. Once you have finalized a deal, you can look forward to a long-lasting business relationship with the manufacturers or suppliers. This way, the marketplace allows you as a distributor to skip the process of shortlisting product manufacturers every time you are looking for in-licensing or distribution deals.

To keep up to the quality standards other than Good Manufacturing Practice approvals that this medicine manufacturers list has, we qualify their companies before they are boarded on the platform. This allows us to screen Nifedipine manufacturers for the quality of the pharmaceutical products’ dossiers and protect against the risk of possible malpractices.