Omega-3 acid ethyl esters

Omega-3 acid ethyl esters are ethyl esters of the omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid, which naturally occur in fish and extracted as an oil. In combination with diet, they treat high blood triglycerides which aim to reduce the risk of pancreatitis. Omega- 3 acid ethyl esters are also used if the blood fat levels have not been fully controlled by diet changes, exercise, decreasing alcohol intake, weight loss regimen, reducing blood sugar in diabetics, and regulating your thyroid hormone levels. Lowering triglycerides and increasing "good" cholesterol reduces the risk for strokes and heart attacks. Omega-3 acid ethyl esters are taken orally as medicines or supplements. Omega-3 acid ethyl esters are sold under the brand names Lovaza and Omtryg among others Pronova made Omega-3 acid ethyl esters were approved in the United States in 2004. Its medicines were approved for medical use in the EU in 2000. Trygg Pharma, Inc’s Omtryg omega-3 acid ethyl esters were one of the most commonly prescribed to more than 3 million people in the United States. However, NHS Scotland prefers it less than statins and does not recommend its use due to lack of evidence for cardiovascular conditions.

Dosage and administration

Omega-3 acid ethyl esters are supplied as a liquid-filled gel capsule and used orally. Each capsule comprises 1.2 grams of omega-3-acid ethyl esters type A, liquid concentrate of 900 mg omega-3-acid ethyl esters at least, and are predominantly a combination of approximately 465 mg of EPA and approximately 375 mg of DHA. Prior to starting the use of this medicine, the patient is assessed for triglyceride levels, and tested for diabetes mellitus, hypothyroidism, or medications of high triglyceride levels, and managed as needed. The patient must have been on a lipid-lowering diet before and maintain that diet for using this therapy. The recommended daily dose is 4 capsules per day, taken as a single dose four times a day. the capsules have to be swallowed whole and should not be broken open, crushed, or dissolved, or chewed.

Price of Omega-3 acid ethyl esters

In the international market, the consumers have to pay a retail price of $208.22 for the supply of 120 capsules of 1g strength. In India, the consumers have to pay a retail price of USD 4 for the supply of 15 capsules of 1g strength.

How do Omega-3 acid ethyl esters work?

Omega-3 acid ethyl esters lower triglyceride production by the liver however, this has been fully understood yet. It also inhibits Acyl-CoA:1,2-diacylglycerol acyltransferase, reducing triglyceride synthesis while improving paroxysmal beta-oxidation, this results in an increase in fat aside from metabolism2. It also inhibits the release of fatty acids by competing for enzymes involved in the synthesis of triglycerides and increases triglyceride clearance by increasing the activity of lipoprotein lipase. Its actions also decrease the production of VLDL-C2.

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