Paclitaxel is a plant alkaloid which is extracted from the bark of the Pacific yew tree Taxus Brevifolia which contains endophytic fungi that synthesize this medicine. It is in a class of medications called antimicrotubule agents. It works by stopping the growth and spread of cancer cells. It is a natural product with antitumor activity and is an immunosuppressant. It is a toxoid antineoplastic agent indicated as a first line therapy and subsequent therapy for the treatment of advanced carcinoma of the ovary and other various cancers including breast cancer, lung cancer, non-small cell and Kaposi’s Sarcoma. This substance is marketed by manufacturers under the Brand name of Taxol, Paxene, Abraxane, Onxol. This pharmaceutical remedy is available in the form of an injectable solution which is administered intravenously (I.V. into a vein). This injection must be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Even when the drug is carefully and correctly administered by trained personnel, this drug may cause feelings of burning and pain. Patients usually have cycles of treatment with a drip into the bloodstream. Each treatment either takes 1 hour, 3 hours or 24hrs. Manufacturers supply 30mg, 100mg, 150mg and 300mg vials in a concentration of 6mg/mL. It vials should be stored in original cartons between 20° - 25° C (68°–77° F). The original package must be retained to protect from light. If refrigerated, the product may precipitate, precipitate redissolved at room temperature with little or no agitation. There is no impact on product quality under these situations. The vial should be discarded, if the solution remains cloudy or if an insoluble precipitate is noted.

Paclitaxel is on the World Health Organization’s List of Essential Medicine, the safest and most effective medicines needed in a Health System. The Mechanism of action is a taxane. This pharmaceutical substance is a novel antimicrotubule agent that binds to the β subunit of tubulin. Tubulin is the building block of microtubules and binding of locks these building blocks in place and simultaneously promotes their assembly and disassembly to form stable, non-functional microtubules. This stabilization of microtubules blocks cells in the M phase of the cell cycle, inhibiting cell division and ultimately causing cell death. It induces programmed cell death in cancer cells by binding to an apoptosis stopping protein called Bcl-2 (B-cell leukemia 2) and thus arresting its function. Finding these medicine’s Manufacturers and paclitaxel Suppliers Finding a trustful partner in our business is one of the major challenge and to overcome that challenge and to make one’s work / life easy in finding the trustful and suitable manufacturer and supplier of this medicine one can visit the Pipelinepharma website which helps you in finding the dependable manufacturers and suppliers of this medicine. Pipelinepharma, which is a business-to-business (B2B) licensing marketplace for pharmaceutical products, quickly connects owners with the buyer for the business development. You can filter the product names in unified search engine by its country, category, therapeutic area, forms, dossier and its status, regulatory filings, approvals, and more.

Paclitaxel is well within the range of existing cytotoxic treatments. The price to wholesalers for each 30mg vial of Taxol will be $146.10, which costs around $1000 for an average three-week cycle of treatment. Depending upon the severity, most patients receive between two and five cycles of therapy. In certain U.S pharmacies, the cost of these intravenous solutions is around $17 for a 5ml supply. In the UK, the wholesale cost of this medicine is about 66.85 GBP and in the developing world it costs around $7.06 to $13.48 per 100mg vial.

Being a global B2B pharmaceutical online marketplace, Pipelinepharma is structured to simplify pharmaceutical deals by providing you with an intuitive interface that is easy to engage with. The selection of Paclitaxel offerings can be narrowed down with the use of filters and easily weighed against one another according to medication prices and commercial terms. The advanced filters help you filter out the countries for these substance manufacturers and these substance suppliers that you are looking for. These also enable you to check the dossier status of this medicine and the GMP approvals of the different variants of this substance. Also, each manufacturer or supplier product description contains essential information about this substance including clinical data, stability zones, countries where this medicine is already registered in. Manufacturers also have special, and delivery terms.

If you are a pharmaceutical licensing company or a distributor you can enter into deals or negotiations over these medicine offers with manufacturing companies after completing the free registration process and joining our online marketplace. This helps to ensure that you conclude the pharmaceutical deal at a reasonable cost and achieve the best cost/benefit ratio for your company while bypassing lengthy sourcing, negotiation, and ordering process. Once you have finalized a deal, you can look forward to a long-lasting business relationship with the manufacturers or suppliers. This way, the marketplace allows you as a distributor to skip the process of shortlisting product manufacturers every time you are looking for in-licensing or distribution deals.

To keep up to the quality standards other than Good Manufacturing Practice approvals that this medicine manufacturers list has, we qualify their companies before they are onboarded on the platform. This allows us to screen Paclitaxel manufacturers for the quality of the pharmaceutical products’ dossiers and protect against the risk of possible malpractices.