Drug Name: Pantoprazole Manufacturer Chemical formulation: C16H15F2N3O4S Active ingredient: Sodium sesquihydrate Common/generic brand name: Protonix Approved by FDA: Yes Commonly marketed: US Density: 1.5±0.1 g/cm3

Pantoprazole is a pharmaceutical drug commonly sold under the brand name “Protonix” and classified as a proton pump inhibitor (PPI). It has an effective mechanism of action and is well known for treating gastrointestinal disorders, mainly peptic ulcers, Zollinger-Ellison syndrome, and interim treatment of Esophagitis when acid leakage is suspected in the esophageal lining. Pantoprazole acts as an antacid and tends to rectify the pH level in the stomach which drops due to excessive gastric acid secretion. It restores the cell damage caused by the secretion of excessive acid and helps to reduce the risk of gastrointestinal ulcers and cancers in the future. Pantoprazole is less likely to create complications on interaction with other drugs. However, a slight difference may occur in the function of the drug when it is administered with Erlotinib, Nelfinavir and Rilpivirine . This pharmaceutical substance is prescribed according to the symptoms like acidity, heartburn, difficulty in swallowing, feeling a lump in the throat, or suspected ulcer. It is used on a large scale as it has been reported to be one of the less harmful PPIs with maximum efficacy. In addition to its active ingredient, it has some inactive ingredients as well, namely calcium stearate, crospovidone, hypromellose, iron oxide, mannitol, methacrylic acid copolymer, polysorbate 80, povidone, propylene glycol, sodium carbonate, sodium lauryl sulfate, titanium dioxide, and triethyl citrate.

There are plenty of drug sources which include, Sun Pharm, Wyeth Pharms, Akorn, Aurobindo Pharma Ltd, Mylan Labs Ltd, Sandoz Inc, Hikma, Actavis Totowa, Amneal Pharms, Atlantide, Dr. Reddys Labs Ltd, Hetero Labs Ltd V, Ingenus Pharms Llc, Jubilant Generics, L Perrigo Co, Lannett Co Inc, Macleods Pharms Ltd, Mylan Pharms Inc, Orchid Hlthcare, Rubicon, Sun Pharm Inds Ltd, Teva, and Torrent Pharms.

Pantoprazole is manufactured in different forms which are prescribed depending on the underlying disease. It is available for oral use in the form of tablets, granules, and suspensions, and for parenteral use as Intravenous injection. Children are usually administered suspensions whereas adults can be prescribed the oral form or the injections. The tablet is manufactured in 2 doses 20mg and 40mg while the suspension and the IV injection are manufactured as 40mg per packet or vial respectively.

Pantoprazole is usually administered via mouth which acts as a delayed-release tablet. The granules work well when taken with applesauce or apple juice. The tablet should be swallowed as a whole, without crushing or chewing it. It can be taken as either a short-term or long-term regimen, depending on the need. The dose may be once or twice a day. Avoid skipping any of the doses. You may notice the alleviation of symptoms immediately after the treatment regimen has commenced but it is advised not to stop the medication before the allotted time. The drug may be taken with or without food.

Patients aged 18yrs and above: 40 mg once a day with or without food up to 8-16 weeks. Children whose weight is 40kg or above are recommended to take the same dose with a maximum duration of 8 weeks. The typical dose for children weighing below 40kg is 20mg once a day for up to 8 weeks. IV injection can be used 40 mg per day up to 7-10 days.

40mg tablet twice a day. IV infusion of 80mg with 8-12hrs of interval for a week or less (depending on the progress of treatment). If the patient is able to take the medication orally then substitute it with tablets.

For Duodenal ulcers: a course of 40mg tablet per day is advised for 2 weeks. For Gastric ulcer: 40mg tablets per day for a month. However, the dosage depends on the patient's age, health condition, status, type of disease, and any suspected allergy.

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Pantoprazole costs $18 for a 40mg tablet and $1.46 for one pack of IV injections.

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This drug may cause some mild side effects which usually get resolved without any medication, however if they persist, consult your doctor. These side effects include vomiting, dizziness, dysentery, vomiting, gas, joint pain, and headache. Depending on the patient’s comorbidities, the drug may show severe side effects which require immediate intervention. These include effects that mostly occur on the skin such as blistering, rashes, itching, and swelling of the face. The person may experience respiratory problems like shortness of breath, tightness in the chest, difficulty in swallowing, arrhythmia, muscle spasms, or effects related to the nervous system like involuntary shaking of the body, fever, and alteration in the renal function like polyuria, oliguria, and hematuria. It may cause some long-term side effects such as osteoporosis, Hypomagnesemia, or malabsorption.

Patients aged 65 and above cannot purchase Pantoprazole without a prescription. Don’t continue the medication for more than a year as it may cause osteoporosis and increase the chances of bone fracture. Report to your doctor if you feel difficulty in walking or sitting. Pantoprazole may influence the results of some tests therefore it is suggested to inform the doctor about the medicine before the test. Don't take any prescribed drug or herbal medicine in combination with Pantoprazole without discussing it with the doctor. Keep regular blood-chemistry checks before and during the treatment regimen,

Pantoprazole has the potential to affect fetal development or produce congenital anomalies in 1% of the subject population. To avoid any harm, it is suggested to take Pantoprazole during pregnancy only when no other alternative can be taken. However, it is mandatory to report to your doctor if you are pregnant before acquiring the prescription, or if you get pregnant during the treatment. This drug may be harmful for lactating mothers and the baby as it is reported that a very small amount of drug is secreted in the breast milk.

Yes, it is recommended by WHO.

1. What is the best time to take Pantoprazole? You can take it at any time but taking the dose an hour before the meal is beneficial. 2. Should I avoid any food with Pantoprazole? Pantoprazole is not affected by any food, but it is suggested to avoid spicy and oily foods as they may increase your symptoms. 3. Is Pantoprazole a prescribed drug or OTC drug (Over-the-counter)? Pantoprazole is a prescription-only drug 4. How long does Pantoprazole remain active in your gut? It remains active for 24hours. 5. How to check whether the drug is working or not? You can easily check whether the drug is beneficial for you by assessing your symptoms. If you notice a reduction in symptoms, the drug is working.