Paricalcitol

Dosage and forms

Paricalcitol is sold as an injectable solution in 2mg and 5mg vials and capsules. The initial dosage prescribed in the treatment of Secondary Hyperparathyroidism is 0.04mg-0.1mg, 3 times a week. In patients who have already progressed to stages, 3 and 4 of chronic kidney disease, a dosage of 1 to 2mcg, up to 3 times a week is prescribed. In children age 10-16, the recommended daily dose in between 1 and 3 mcg, whereas for children younger than that, the doctor decides on the dosage.

The wholesale cost of Paricalcitol

In the USA, Paricalcitol intravenous solution (2 mcg/mL) costs around $94 for a supply of 25 ml, whereas the same quantity of medicine can cost from 60pounds per month onwards.

How does Paricalcitol work?

It is an analogue of 1,25-dihydroxyergocalciferol, the active form of vitamin D₂ and is an agonist of the vitamin D receptor which lowers parathyroid hormone levels. Vitamin D needs two sequential hydroxylations inside the liver and the kidney to bind and activate the vitamin D receptor (VDR). It works by binding to the vitamin D receptor and has been shown to reduce parathyroid hormone levels. Paricalcitol increases the expression of a tumor- suppressor gene, resulting in tumor cell suicide and tumor cell differentiation into normal its form and structure observable. Paricalcitol reduces parathyroid hormone levels and may help better absorb calcium and phosphorus.

Finding Paricalcitol manufacturers and suppliers