Perindopril Erbumine

Perindopril Erbumine a long-acting ACE inhibitor. It is used in the treatment of several conditions such as essential hypertension, stable coronary artery disease, where it lowers the risk of cardiac events in patients with a history of myocardial infarction or in revascularization treatment of symptomatic heart disease or heart failure, and diabetic nephropathy. Perindopril Erbumine is a prodrug, and is hydrolyzed to its active metabolite in the liver called Perindoprilat. When used with Indapamide, it significantly reduces the progression of chronic kidney disease and renal complications in patients with type 2 diabetes. Perindopril Erbumine is sold under the brand name Aceon among others. Science Union & Cie, from France, file the first patent in 1980. In 1986, Warner-Lambert Company filed patents in the USA and approved for medical use in 1988. However, after the expiry of protection of the initial patent, it is now manufactured as a generic drug in many countries.

Dosage and Administration

In the treatment of Hypertension, for Uncomplicated Hypertensive Patients, the recommended initial dose is 4 mg, taken orally once a day for essential hypertension, which can be titrated as needed. But the maximum daily dose is capped at 16 mg. this is followed by a maintenance dose, in the range is 4 mg to 8 mg. For Elderly Patients, the dose is 4 mg daily and a dosage above 8 mg is given carefully after blood pressure monitoring. In use with Diuretics, symptomatic hypotension could occur after the first dose, so doctors will consider administering diuretic prior to starting Perindopril Erbumine. In the treatment of Stable Coronary Artery Disease, the initial dose is set at 4 mg, taken orally once daily for 2 weeks which can be increased to a maintenance dose of 8 mg once daily. For the elderly, older than 70 years, the initial dose is 2 mg, once daily in the first week. It is followed with a maintenance dose of 4 mg dose, taken once daily in the second week and 8 mg, taken once daily.

The price of Perindopril Erbumine

In the USA, the consumers have to pay an average cost of $71.99, for a supply of 30 Tablets of 4mg each of the generic brands. This medicine is significantly cheaper in the developing world. In India, a supply of 30 tablets of 8mg strength costs around USD 6.

How does it work?

Perindopril erbumine is a pro-drug for perindoprilat. Its actions inhibit the angiotensin-converting the enzyme (ACE). Like other medicines of its class, it relaxes and widens the blood vessels. The resulting action is a lowering in blood pressure which makes it easier for your heart to pump blood, thus improve the symptoms of heart failure.

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