Phenibut

Phenibut is a central nervous system depressant. Its actions have anxiolytic effects, making it suitable for treating anxiety, insomnia, and a variety of conditions. It is related to GABA and is a GABA analog. It sold only in Russia, Ukraine, Belarus, and Latvia to treat anxiety, improve sleep and asthenia, depression, alcoholism, alcohol withdrawal syndrome, post-traumatic stress disorder, stuttering, tics, vestibular disorders, Ménière's disease, dizziness, preventing motion sickness, and in preventing of anxiety pre or post-surgical or diagnostic tests that cause pain. Phenibut is marketed under the brand names Ambien, Fenibut, Bifren, and Nurofen. Professor Vsevolod Perekalin's team at the A. I. Herzen Leningrad Pedagogical Institute (USSR) synthesized and tested it at the Institute of Experimental Medicine, USSR Academy of Medical Sciences. In Russia, It started selling for clinical use in the 1960s.

Dosage and administration

Phenibut is available as a powder of 40-98% purity or capsules in 200-500 mg doses and usually taken orally as a tablet or can be given intravenously. The dosage is between 500 to 2000 mg. the therapeutic dose is 250-750 mg, while the low to medium recreational dose is 1000-1500 mg, the medium to high dose, between1500- 2000 mg.

The price of Phenibut

The price of Phenibut can vary between $0.30 to $1.00 for a gram. In the API market, the price of 125grams is around $28.

How does it work?

It acts the same way gabapentinoids such as gabapentin and pregabalin do. It is postulated to act like a GABAB receptor agonist, like baclofen and γ-hydroxybutyrate (GHB) and a blocker of subunit-containing voltage-dependent calcium channels. It is a full agonist and has between 30 to 68 times lower affinity for the GABAB receptor than baclofen and more than 100-fold higher affinity for the GABAB receptor.

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