Prednisolone Acetate is a corticosteroid medication that is useful for reducing inflammation. Which Mainly leads to a reduction in pain and improvement of a variety of symptoms associated with injury, inflammation, and allergy. This drug is marketed with the Brand Name SOLU-MEDROL Prednisolone Acetate is used for emergency or acute type conditions where a rapid response is required. The main uses of Prednisolone Acetate include Severe allergic reactions –therefore this pharmaceutical remedy should be given after immediate treatment with adrenaline or an Epipen. Severe skin reactions are secondary to drugs and other causes. Status asthmaticus (severe asthma attacks)- Although this drug does not act immediately it should still be given in the event of an acute attack. Suppression of transplant rejection. Cerebral edema (swelling due to fluid). Inflammatory bowel disease in severely ill patients. Systemic lupus erythematosus (a multi-system inflammatory disorder). Shock due to shutdown of the adrenal gland (a gland involved in secreting steroids). Rheumatic disorders– Useful in acute attacks. Certain types of meningitis and pneumonia are also considered. This medication basically means that it is a steroid medication produced in the centre (cortex) of the adrenal gland. Methylprednisolone has a specific ‘glucocorticoid’ effect meaning that it predominantly acts to reduce the body’s normal inflammation and immune responses. It achieves this by altering the expression of various genes within tissue cells. Like the other steroids, methylprednisolone also causes mild water and salt retention in the kidneys. However, this effect has far less potency toward it. This pharmaceutical medicine is supplied as a dry white powder that requires dissolution in special water before administration. Methylprednisolone is given either by injection into a muscle (such as the buttocks) or as a slow injection or infusion into a vein. This drug should only be administered by experienced medical personnel. Two different strengths of this pharmaceutical remedy are currently available which are 500mg (in a 20mL glass vial) or 1000mg (in a 30mL glass vial). This drug should be stored at 20° C to 25° C (68° F - 77° F). Disorientation, difficulty sleeping, changes in appetite, increased perspiration, acne, or pain/redness/swelling at the injection site are all possible side effects of this medication. Inactive chemicals may be included in this product, causing allergic reactions or other issues. Tell your doctor or pharmacist about any of the following medical conditions before taking this medication: bleeding problems, blood clots, brittle bones, diabetes, eye diseases, heart problems, high blood pressure, current/past infections, kidney disease, and liver disease. Aldesleukin, Mifepristone, and other drugs that might induce bleeding or bruising (such as antiplatelet pharmaceuticals like Clopidogrel, "blood thinners" like Warfarin/Dabigatran, NSAIDs like Ibuprofen, Celecoxib, Aspirin, and Salicylates) are some of the products that may interact with this drug.

The wholesale price of injectable powder for injection (1 g preservative-free) is around $72 for a supply of 1 powder for injection, The cost for injectable powder for injection (40 g preservative-free) is around $ 167.29 for a supply of 25 powder for injection.

Methylprednisolone binds and activates specific nuclear receptors, which are resulting in altered gene expression by the inhibition of proinflammatory cytokine production. The produced agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. It also acts as in to various ways to decrease the inflammatory cycle including: dampening the inflammatory cytokine cascade, inhibiting the activation of T cells, decreasing the extravasation of immune cells into the central nervous system, facilitating the apoptosis of activated immune cells, and indirectly decreasing the cytotoxic effects of nitric oxide and tumour necrosis factor-alpha.

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