Salbutamol sulfate (Salbuterol) is a medication used to treat asthma, exercise-induced bronchoconstriction, and chronic obstructive pulmonary disease. It is available in the market in single-ingredient form as 90mcg albuterol inhalation aerosol, 0.63 mg/3ml, 1.25mg/ml, 2.5mg/3ml or 5mg/ml albuterol inhalation solutions, and 2mg, 4mg, or 8mg albuterol tablets, as well as in oral solution form. However, it is also commonly used in combination medications along with ingredients such as guaifenesin, ambroxol, and ipratropium, among others. Albuterol belongs to a class of drugs known as adrenergic bronchodilators. Other medications in this class that are effective substitutes for albuterol are isoproterenol, arformoterol, salmeterol, levalbuterol. That being said, albuterol is the most popular of the abovementioned drugs. In fact, in 2016 albuterol was the 10th most prescribed drug in the U.S., reaching over 47 million subscriptions per year. It is also one of the drugs included in the World Health Organisation's list of Essential Medicines that contains the safest and most effective drugs recommended for a health system The drug is available in both branded and generic versions. The most popular trade name medication with the active ingredient albuterol is Ventolin, from supplier Glaxo Smith Kline. Other manufacturers and suppliers that control a sizeable share of the global albuterol medication market include Merck & Co., Teva, and Mylan.

Salbutamol, when compared to isoproterenol, has a preferential action on beta2-adrenergic receptors in vitro and in vivo pharmacologic investigations. Although beta2 adrenoceptors are the most common adrenergic receptors in bronchial smooth muscle and beta1 adrenoceptors are the most common receptors in the heart, beta2-adrenoceptors account for 10% to 50% of total beta-adrenoceptors in the human heart. Although the exact role of these transmitters has yet to be determined, their presence suggests that even pure beta2-agonists could have cardiovascular impacts. When beta2-adrenergic transmitters on airway smooth muscle are activated, adenyl cyclase is activated, and the extracellular concentration of cyclic-3′,5′-adenosine phosphorylated rises (cyclic AMP). This rise in cyclic AMP causes protein kinase A to become activated, inhibiting myosin phosphorylation and lowering intracellular ionic calcium contents, resulting in relaxation. From the tracheal to the terminal bronchioles, salbutamol helps reduce inflammation of all airways. Salbutamol works as a functional blocker to relax the airway regardless of the spasmogen, defending against every bronchoconstrictor threat. Increased cyclic AMP levels are also linked to a reduction in the production of mediators by mast cells inside the trachea. In most controlled studies, salbutamol has indeed been proven to have a greater effect on the respiratory system, in the shape of smooth muscle stress relief, than resveratrol at similar doses, while having fewer cardiac side effects. Ingested albuterol, like other beta-adrenergic antagonist medications, has been demonstrated in controlled clinical research and other clinical skills to have a substantial cardiovascular impact in some patients, as evaluated by pulse rate, heart rate, sensations, and/or echocardiographic alterations.

Based on the drugstore you go, the approximate retail prices per inhalable suspension of salbuterol (totaling 200 inhalations) in the US are 3-4 USD, while 30 tablets cost around 2-4 USD. The approximate retail prices per inhalable suspension of salbuterol (totaling 200 inhalations) in the EU are 3-4 EUR, while 30 tablets cost around 2-4 EUR. Costs are only applicable for cash-paying consumers and do not apply to insurance plans. Pharmaceutical corporations generally fund patient assistance programs, which provide free or subsidized drugs to low-income, unemployed, or under-insured patients who meet certain criteria.

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