Scopolamine

Scopolamine is from a class of medications called antimuscarinics. They prevent nausea and vomiting caused by motion sickness and medications used in surgery. They block the effects of acetylcholine on the central nervous system. It has a wide range of medical uses which include, Postoperative nausea and vomiting, Motion & seasickness, Gastrointestinal, Renal or biliary spasms, Irritable bowel syndrome, Clozapine-induced drooling, Bowel colic, Eye inflammation, and as an aid in gastrointestinal radiology and endoscopy. It can also reduce respiratory tract secretions and decrease saliva during surgery. Effects begin after about 20 minutes when injected and can last for up to 8 hours. Hyoscine is the main active component in Scopolamine. It is produced by certain plants of the nightshade family, use as psychoactive drugs due to their hallucinogenic effects. The name " Scopolamine" comes from nightshade known as Scopolia. Scopolamine is sold under the brand names Transdermscop, Kwells among others. Scopolamine was first written about in 1881 and came into use as anesthesia around 1900. Scopolamine also features on the WHO's List of Essential Medicines to be present in any medical system.

Dosage Forms & Strengths

Scopolamine is sold as a transdermal patch of 1mg which can be changed every 3 days or 72 hours. In the treatment of Nausea & Vomiting, the dose is 0.3-0.65 mg via IV/IM/SC, repeated every 8 hours when needed. For preventing Motion Sickness, the user has to apply one patch behind the ear 12 hours before exposure to motion. To prevent Nausea & Vomiting Associated with Anesthesia, one A transdermal patch is applied behind the ear on the night before scheduled surgery and left there for 24 hours post-surgery. In Cesarian section’s the mother is applied 1 patch behind the ear, one hour prior to surgery and removed 24 hours after surgery and for Chemotherapy Induced Nausea and Vomiting the user Apply 1 patch every 3 days.

The price of Scopolamine

In the USA, the consumers pay an average cost of $75.59 for 1 Box with 4 patches for 72 hours. In India, the price of the 10 patches is around USD 25.

How does Scopolamine work?

Scopolamine is a belladonna alkaloid that is an anticholinergic. Scopolamine competitively inhibits at postganglionic muscarinic receptor sites of the parasympathetic nervous system and on smooth muscles lacking cholinergic innervation that respond to acetylcholine. Its actions prevent brain signals between the nerves of the vestibule and the vomiting center in the brain. It does this blocking the action of acetylcholine. As it works directly on the brain center, it has to be taken prior to the anticipated motion or surgery.

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