SILYBUM MARIANUM

Silybum marianum also called Cardus Marianus or blessed milk or Marian or Mary or Saint Mary's or Mediterranean milk or variegated or Scotch thistle is an annual or biennial plant of the family Asteraceae. Since ancient times, it is known for its active flavonolignans constituents groups, called Silymarin. It is found only in the seed shell. Silybum marianum has liver- protective and regenerative properties, in addition to its antioxidant effects. It is also used to treat diabetes in combination with frontline therapy, for liver disease although it has yet to be proven effective. Silybum marianum is sold under the brand name Puritan's Pride, Jarrow Formulas, FarmHaven, and Nature’s bounty among others. Silybum marianum research started in Germany in the 1950s. The FDA is yet to review Silybum marianum for safety or effectiveness.

Dosages and administration

Milk thistle is safe in dosages of 420 mg per day. it is taken orally in divided doses for up to 41 months. There are also daily doses of 12 to 15 g of dry fruits for dyspepsia and disorders of the biliary system. its extract containing 200 to 400 mg per day is effective in various liver disorders. This product is consumed as directly as it comes in several forms. When unsure about the quantity and in case of adverse side effects, the patient should immediately see a doctor.

The price of Silybum marianum

It is sold OTC, and Prescribed for Life. 4 oz (113 g) Milk Thistle with 80% Silymarin extracted Natural Seed Extract Powder cost $2499and Milk Thistle Extract Powder 250 Grams costs $2496. In the developing world countries, for example in India, a kilo of this powder can cost as low as USD3, depending on the brand, quality, and purity.

How does it work?

Silymarin has hepatoprotective and regenerative properties and action. Its actions reduce FR formed by toxins that damage the cell membranes, it also competitively inhibits hepatocyte external cell membrane modification. By forming a complex it stops the entrance of toxins into the interior of liver cells. Additionally, it metabolically stimulates hepatic cells and activates the RNA biosynthesis of ribosomes to stimulate protein formation.

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