SISOMICIN SULFATE

Sisomicin Sulfate is the sulfate salt form of Sisomicin. It is an aminoglycoside antibiotic used in the treatment of bacterial infections, bacterial skin infections, treating infected or cut wounds. It is a newer broad-spectrum aminoglycoside related to gentamicin and isolated from the fermentation broth of a new species of the genus Micromonospora. Sisomicin is the highly active aminoglycoside against Gram-positive bacteria, Pseudomonas aeruginosa. Sisomicin is effective in treating infections that were not cured by the first-line therapy or were due to microorganisms’ resistance in vitro to other aminoglycosides in some recent studies. Its actions stop the growth of bacteria, thus resolve the symptoms. Sisomicin Sulfate is sold under the brand names Sisorest, sis next, Pitocin, Isoptin, gentamycin, sisowill amongst others. Schering Corp filed the first patent for Sisomicin Sulfate with USFDA in 1971 for methods for production. Chino in Gyogyszer es Vegyeszeti Termekek Gyara Zrt is the current assignee of the newest patent issued in 1983.

Dosage and administration

Sisomicin Sulfate is sold as cream (0.01%) and injection of 10mg/ml ad eye drops. It is administered as Ophthalmic drops, Intramuscular injection, and topically cream. For Susceptible infections, the usual adult dose is 3 mg per kilo of body weight per day, injected Intramuscularly in 2-3 divided doses. When using the Ophthalmic drops, the patient has to instill one or two drops into the affected eyes. When using Topically, its 0.1% cream is applied twice daily.

The Price of Sisomicin Sulfate

In the global ingredient market, the price of 500mg of Sisomicin Sulfate costs around USD245. In India, the cream costs USD1.2 for a supply of 1mg.

How does it work?

Sisomicin is an antibiotic. Its actions prevent essential protein synthesis required by bacteria to carry out vital functions. This preventive action treats skin infections. It exerts its bactericidal action against gram-negative organisms & some gram-positive organisms through inhibition of bacterial protein synthesis. First, it penetrates the bacterial cell membrane & binds directly to the bacterial ribosome, where it misleads mRNA codon by the bacterial ribosome. This creates peptide chains with the wrong amino acid sequence which gets incorporated into the bacterial cell membrane. This eventually alters its permeability leading to Bacterial cell lysis.

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