SPECTINOMYCIN HYDROCHLORIDE

Spectinomycin Hydrochloride is the hydrochloride salt of Spectinomycin. It is an aminocyclitol antibiotic derived from Streptomyces spectabilis, and it has bactericidal properties. When injected into a muscle It is most commonly used to treat gonorrhea infections. Spectinomycin Hydrochloride belongs to the aminocyclitol class of medicines that benefit the patient by stopping the making of protein by harmful bacteria. Streptomyces spectabilis are used to make Spectinomycin Hydrochloride, and is active against gram-negative bacteria. Spectinomycin Hydrochloride is also given to patients whose previous antibiotic therapy failed to cure the infection. Spectinomycin Hydrochloride is sold under the brand names Trobicin, Myspec, Spectrum among others. Upjohn Company’s researchers discovered Spectinomycin in 1961. Its safety and efficacy profile has led to it finding a place on the World Health Organization's List of Essential Medicines, as among the safest and most effective medicines required in any health system. It is not available in the United States anymore.

Dosage and Administration

Spectinomycin is sold as a powder for injection for preparation of a drug for Intramuscular Injection. It comes as a sterile powder of 2 grams for reconstitution with 3.2 mL of Sterile Water for Injection, USP. After adding Sterile Water for Injection, the vials should be stirred vigorously immediately and before the withdrawing dose. A 20-gauge needle with a disposable syringe is the recommended way to administer. When being given as an Intramuscular injection, the dose for adults, both Men, and Women is 5 mL, injected intramuscularly for a 2-gram dose, deep into the upper outer quadrant of the gluteal muscle. In geographic areas with high antibiotic resistance, the initial dose starts with 4 grams or 10 mL, where the the10-mL injection is divided between two gluteal injection sites.

The price of Spectinomycin hydrochloride

Spectinomycin powder, BioReagent, suitable for cell culture is sold for USD100 for a supply of 5g. for the injection containing Spectinomycin, the consumer in India pays USD 2.6 for a supply of one, 2gm injection. This medicine is approved for sale in the USA.

How does it work?

Spectinomycin hydrochloride actions bind to the bacterial 30S ribosomal subunit. There they inhibit peptide elongation and protein synthesis. This leads to bacterial cell death.

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