Tirofiban

Tirofiban is an antiplatelet drug. Tirofiban reduces the frequency of thrombotic cardiovascular events. These events combine endpoint of death, myocardial infarction, or refractory ischemia/repeat the cardiac procedure in patients with non-ST elevation acute coronary syndrome. Its actions prevent blood from clotting during episodes of chest pain or a heart attack, or during procedures related to the blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein receptor. It works by inhibiting platelet aggregation. Tirofiban is marketed under the brand name Aggrastat amongst others.  Baxter Healthcare Corporation first filed for a patent of Tirofiban. It was first approved in the US in 2000. Medicare Pharma in the USA markets it.

Forms and Dose:

Tirofiban is available for premixed IV infusion solution in 5mg/100mL and 12.5mg/250mL, and for IV solution vials in 5mg/100mL vialand 3.75mg/15mL bolus vials. In the treatment of Non-ST Elevation Acute Coronary Syndrome, the recommended loading dose is 25 mcg per kilo IV infused within 5 minutes, to reduce the rate of thrombotic cardiovascular events. The post-loading dose is limited to 0.15 mcg per kilo per minute of IV for up to 18 hr. 

The price of Tirofiban:

In the USA, the average price consumers pay for the intravenous solution of 250 mcg/mL is around $68 for a supply of 15 millilitres. However, the price in India for a generic version of this medicine is lower at USD200 for a supply of 50ml. 

How does Tirofiban work?

Tirofiban’s action provide relief by preventing the formation of blood clots during chest pain or heart attack episodes, or while undergoing a procedure related to the blocked coronary artery. Its primary action inhibits platelet aggregation. When administered intravenously, as per the recommended regimen, more than 90% inhibition is attained within 30-minutes of the infusion. 

Finding Tirofiban Manufacturers and Suppliers:

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