VITAMIN—B1
Vitamin-B1 also called Thiamine is an essential vitamin. Humans gets thiamine from their diet in order to stay healthy. Low thiamine levels in the body is associated with adverse events. Thiamine is absorbed in the intestine by a transporter protein made by the SLC19A3 gene. This gene gives instructions to produce thiamine transporter protein, which moves thiamine into cells. Drugs, like metformin and trimethoprim, have been shown to interrupt function of the SLC19A3 gene. Vitamin B1 acts as a as enzyme cofactors or the precursors to Cofactors.
A wide range of biochemical functions involves Vitamin B1. It is a micronutrient needed by organisms in small quantities for healthy metabolism. Essential nutrients are not synthesized at all or not in sufficient quantities, so must be supplemented through diet.
Vitamin B1 is found in food, manufactured as a dietary supplement and medication. Vitamin B1is present in whole grains, legumes, and some meats and fish. Thiamine supplements well tolerated in the general populations with very low incidence of Allergic reactions
Thiamine was first discovered in 1897. It has the distinction of being the first vitamin to be isolated, and was first made in 1936. Due to its efficacy, the World Health Organization's has included it on its List of Essential Medicines.
Usage and Dosage:
Vitamin B1 is sold in several forms like tablet, capsule, extended release tablet and liquid. The recommended dose for adults in the treatment and prevention of Beriberi-Thiamine Deficiency is 10 to 20 mg, administered intramuscularly, three times daily, for up to 2 weeks. After that patient is moved to an oral dose of 5 to 10 mg thiamine daily for one month. In the Neuritis of pregnancy, to preclude oral therapy, the dose is set at give 5 to 10 mg, given intramuscularly everyday. In the treatment of an emergency cardiac condition like 'Wet' with myocardial failure, the Intravenous route gives it slowly.
While making up for Thiamine Deficiency, the recommended Adult Dose, If dextrose administered is 100 mg in each of the first few liters of Intravenous fluid to avoid precipitating heart failure, and dose of 50 to 100 mg is enough twice a day is the dose when take as supplement. The initial dose when treating Wernicke's Encephalopathy is 100 mg, given Intravenoiusly followed by 50 to 100 mg per day IM or IV until the patient is on a regular, balanced, diet. The Usual Pediatric Dose for treating Beriberi is 10 to 25 mg IM or IV daily if critically ill, or 10 to 50 mg, taken orally. everyday, for a period of 2 weeks, then the dose is reduced to 5 to 10 mg, to be taken orally, daily for 1 month.
The price of Vitamin B1:
This is relatively inexpensive medicine. In the USA, for the OTC supplement supply of 100 tablets of 100mg each, the consumers have to pay as little as US$7. The price is cheaper still in the developing and under developed world, where it is an essential part of the nation diet programs. The price of the same supply of this supplement will cost as little as USD 1 India for a generic brand of B1.
How does Vitamin B1 work?
Thiamin aids body's cells change carbohydrates into energy. Carbohydrates provide energy for the body, especially the brain and nervous system. Thiamin also vital to muscle contraction and conduction of nerve signals. Thiamin is essential for the metabolism.
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