Vitamin B6

Vitamin B6 is water-soluble and in coenzyme forms, performs a wide variety of functions in the body. It is known to be extremely versatile, with involvement in over 100 enzyme reactions, mostly concerned with protein metabolism. Vitamin B6 is the generic name of six compounds namely pyridoxine, alcohol, pyridoxal, an aldehyde, and pyridoxamine, which contains an amino group and their respective 5’-phosphate esters and pyridoxamine 5’ phosphate are it’s coenzyme forms. It naturally occurs in diet, added to others, and even available as a dietary supplement like fruits, vegetables, and grains that exist in glycosylated forms. Vitamin B6 also plays a role in cognitive development as it enables the biosynthesis of neurotransmitters and in maintaining normal levels of homocysteine. It is also involved in gluconeogenesis and glycogenolysis, immune function, and hemoglobin formation. It is also recommended in preventing and treating low levels of pyridoxine deficiency and the resulting anemia. It is also used in the treatment of heart disease, Premenstrual syndrome, and depression including other conditions. Vitamin B6 is sold under the brand name Nestrex to name one. It is available a hundreds of brands in many products and formulations treating so many conditions. It is one of the most commonly occurring deficiency and thus governments and companies have ensured that there are supplier, labelers and manufacturers around the world.

Dosing

The oral dose for adults when the body makes abnormal red blood cells that build up iron called sideroblastic anemia, the initial dose is 200-600 mg and then decreased to 30-50 mg per day after an adequate response. For treating vitamin B6 deficiency the dose for most adults is 2.5-25 mg daily for three weeks then 1.5-2.5 mg per day. In the reduction of high levels of homocysteine in the blood, the dose is 50-200 mg In the treatment of conditions causing eye disease leading to vision loss in older adults the dose is 50 mg of with 1000 mcg of vitamin B12 and 2500 mcg of folic acid for about 7 years and For kidney stones, the prescribed dose is 25-500 mg daily. In the treatment of morning sickness, the mother is given 10-25 mg, taken three or four times per day and in the treatment of symptoms of premenstrual syndrome, the standard dose is 50-100 mg, used daily along with 200 mg of magnesium.

The cost of Vitamin B6

In the USA, the consumers pay an average retail price of $3.20 for 30 tabs of 25mg. In India, the cost of 100 tablets of the same strength is only USD1.

How does Vitamin B6 work?

Vitamin B6 (Pyridoxine) is needed for the proper function of sugars, fats, and proteins in the body. It is also required for the proper growth and development of the brain, nerves, skin, and many other parts of the body. The 4-methanol form, pyridoxine gets converted into pyridoxal 5-phosphate, which is an important coenzyme for synthesis of amino acids, neurotransmitters, sphingolipids, and aminolevulinic acid. Vitamin B6, in its biologically active coenzyme form, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, synthesis of nucleic acids, hemogloblin, sphingomyelin, and sphingolipids. It is also responsible for the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine, and gamma-aminobutyric acid.

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