Naftidrofuryl Oxalate Manufacturers

This Naftidrofuryl Oxalate belongs to the class of organic compounds known as naphthalenes. Naftidrofuryl (INN), also known as nafronyl or oxalate salt naftidrofuryl oxalate or nafronyl oxalate, is a vasodilator used for the management of peripheral and cerebral vascular disorders. This drug act as a selective antagonist of 5-HT2 receptors. Naftidrofuryl is marketed widely under a variety of Brand names, including Artocoron, Azunaftil, Di-Octane, Dusodril, Enelbin, Felix, Gevatran, Iridus, Iridux, Luctor, Nafti, Naftoling, Naftodril, Nafoxal, Praxilene, Sodipryl retard, and Vascuprax. Paraxylene belongs to a group of medicines known as ‘metabolic activators. These are used to treat different types of blood circulation problems. Naftidrofuryl Oxalate allows the body to make better use of the oxygen in the blood. Naftidrofuryl Oxalate is also used to treat the following symptoms: cramp-like pains; cramps in legs at night; severe pain in r legs when people are resting (rest pain); pale or blue fingers or toes which get worse when it is cold; numbness, tingling or burning feeling in the fingers or toes (Raynaud’s syndrome or acrocyanosis); open sores on the legs or feet (trophic ulcers); poor circulation caused by diabetes (diabetic arteriopathy). Common side effects Naftidrofuryl has been associated with nausea, abdominal pain, and rash. Rarely, hepatitis and liver failure have been reported. In the naftidrofuryl group, the proportion of gastric disorders was higher with a risk difference of 2.85% (95% CI 0.78–4.91%) compared with placebo. The reported gastric adverse events were minor side effects such as nausea, epigastric pain, oesophagitis, and diarrhea. Adults and the elderly population - One or two 100mg capsules three times daily for a minimum of three months, or at the discretion of the physician. Naftidrofuryl are pink, hard gelatin capsules (size 2) printed “C” and “NL” in black. Pack sizes are 84 capsules. The capsules should be administered with enough water (one glass) during or after food. The product containers are rigid injection molded polypropylene containers with snap-on polyethylene lids. The product may also be supplied in blister packs in cartons: Blister pack: (i) 250µm white rigid PVC/PVdC. (ii) Surface printed 20µm hard temper aluminum foil with 5-7g/M2 PVC and PVdC compatible heat seal lacquer on the reverse side. Store below 25°C in a dry place. Protect from light.

Wholesale Price of Naftidrofuryl Oxalate

In Canada, the wholesale price of Naftidrofuryl Oxalate oral tablet costs around $ 55.5 per tablet for a quantity of 84 tablets.

Naftidrofuryl Oxalate - Mechanism of action

Naftidrofuryl (NFT) is a selective inhibitor of serotonin 5-HT2 receptors (5-HTR) blocking the vasoconstrictive effect of 5-HT released from endothelial cells and platelets in response to hypoxia and atherogenesis and inhibits serotonin mediated platelet aggregation. It promotes vasodilatation by antagonizing endogenous vasoconstrictor cytokine endothelin 1, increasing nitric oxide (NO) levels, a potent vasodilator, and an inhibitor of platelet aggregation and platelet induced vasospasm. Nitric oxide inhibits intercellular adhesion molecule-1 (ICAM-1) upregulation in endothelial cells upon stimulation by TNF-α, the latter being important for leukocyte recruitment in the atherosclerotic process.

Finding Naftidrofuryl Oxalate Manufacturers and Suppliers

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