epirubicin
Solution for injection
2 mg/ml
- 5 ml, 10 ml, 100 ml, 25 ml
Manufacturer usually replies in 14 days
Dossier type
EU CTD
Dossier status
Ready to file
Country of origin
European Union
GMP approvals
EU GMP
Registered in
Germany
Available for
Licensing with supply, Distribution only
Manufacturer #16717
They've been serving and assisting customers in the healthcare business in Regulatory Affairs and Pharmacovigilance for over 30 years. This sphere of action covers many countries around the world. They look after their local and European consumers and the supply chain by providing high-quality products for internationalization strategies.
Manufacturer usually replies in 14 days
Epirubicin
Epirubicin used for chemotherapy is an anthracycline drug. It can be used to treat breast
cancer, who already had surgery to remove the tumor. Epirubicin primarily treats breast and
ovarian cancer, gastric cancer, lung cancer, and lymphomas. Like all anthracyclines,
Epirubicin intercalates DNA strands resulting in complex formation. This complex inhibits
DNA and RNA synthesis. Epirubicin kicks off DNA cleavage by topoisomerase II, which
results in a mechanism leading to cell death. It is thought that it works by binding to the cell
membranes and plasma proteins in the compound's cytotoxic effects. But it generates free
radicals that cause DNA and cell damage. In some chemotherapies, it is favored over
Doxorubicin, the most popular anthracycline because it has fewer side effects. Epirubicins
different spatial orientation caused by hydroxyl group with opposite chirality accounts for its
faster elimination and lower toxicity.
Pfizer sells Epirubicin under the brand name Ellence, Pharmorubicin, or Epirubicin Ebewe in
the USA and around the world.
Upjohn applied for FDA approval for its node-positive breast cancer in 1984 but was turned
down due to of lack of data. However, the first trials of Epirubicin in humans started and was
published in the early 80s. In 1999 Pharmacia who by then merged with Upjohn, received
FDA approval for the use as a component of adjuvant therapy in node-positive patients,
however, this Patent protection expired in 2007.
Dosage and administration
Epirubicin is sold as a solution for injection. It is given through the intravenous injection route
by placing the needle directly into the tube of a flowing IV solution, that goes into a vein or
central line. Epirubicin is a vesicant and can cause extensive tissue damage and blistering if
it escapes from the vein. Therefore it is critical that, it is administered by a nurse trained to
gives this drug. Any signs of inflammation around the injected area call for immediate
medical intervention.
The cost of Epirubicin
In the USA, the cost for an intravenous solution containing 2 mg is around $50 for a supply
of 5 milliliters. Whereas in India, a supply of 10 Mg costs only USD 7.5.
How does Epirubicin Work?
Epirubicin, an antitumor antibiotic is made from natural products of species of the soil fungus
Streptomyces. They are involved in actions during the multiple phases of the cell cycle and
are considered cell-cycle specific. Chemotherapy that works well when cells are dividing is
called cell-cycle specific therapies. The scheduling of injection is subject to the type of cells,
the rate at which it divides, and the time when it is likely to have the most impact.
Finding Epirubicin Manufacturers and Suppliers:
The process of finding trusted Epirubicin manufacturers and Epirubicin suppliers can be
made quicker and more accessible by using Pipelinepharma's online platform, a B2B
a marketplace that lets you finalize the deals of pharmaceutical products in a matter of a few
clicks. Also, it is easy to use the online platform to grow your business opportunities.
The robust search engine makes it convenient to search for manufacturers and suppliers of
Epirubicin. The search can be further refined with industry-specific filters such as dossier
type, country of origin, GMP approvals, and search criteria for Wholesaler, etc. helping to get
in contact with the preferred manufacturer and supplier readily.