This global pharmaceutical company specializes in a wide range of dosage forms, including capsules, creams, injections, oral solids, and transdermal patches. They are renowned as the world's largest manufacturer of suppositories and pessaries. Their product portfolio spans several key therapy areas such as pain management, women's health, and dermatology. They hold GMP certifications and have patents on numerous products. The company operates state-of-the-art manufacturing facilities in multiple regions including the EU and North America, ensuring a global reach for their pharmaceutical offerings.
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Phloroglucinol
Phloroglucinol an organic compound commonly used in making medicines and other industrial
purposes. It is one of the three main isomeric benzenetriols. It key property is to provide relief
from abnormal and painful contractions in the intestine, bile ducts, urinary tract, and uterus. Due
to these anti-spasmodic properties, it is used to control, prevent & improve conditions, and
symptoms of Irritable bowel syndrome, Bladder spasm after transurethral resection of the
prostate, gallstones, spasmodic pain, and other related gastrointestinal illnesses and
complications. A suppository form is used in giving relief from pain during spasmodic
gynecological issues and for relief from caused by contraction during pregnancy. Phloroglucinol
has a polyphenolic compound chemical structure that includes an aromatic phenyl ring with
three hydroxyl groups. It is a derivative of phenol, that provides cyctoprotective effect from
oxidative damage by increasing cellular catalase activity.
Phloroglucinol is sold under the brand names Actafon, AnaSpasm-Oro, and Bruglucen among
others.
Akzona Inc filed for the first patent of Phloroglucinol in Japan in 1979. However, the USFDA has
not approved it for sale in the USA. Phloroglucinol is approved for sales in Japan, Russia, and
some parts of Europe. Teva pharmaceuticals also sells a suppository in Europe for use in
painful spasmodic manifestations in gynaecology and contractions during pregnancy.
Dosage and administration
Phloroglucinol is available as tablets, chewable tablets comprising from 40mg, 80mg and a150
mg suppository in some markets. It is a water-soluble diluent. Its oral lyophilisate and coated
tablet are sold in 80mg strength and also as a solution for injection of 10mg/ml, and as a
suppository of 150mg.
Phloroglucinol is commonly administered as tablets, by dissolving them in a glass of water or
can be placed under the tongue for much fast action. The recommended usual adult dose is 2
tablets, taken at the time of the crisis, and repeated in case of major spasms. For the pediatric
population, the recommended dose is 1 tablet, dissolved in a glass of water, taken two times a
day.
The suppository is administered rectally, only one a day, as per the prescription of the doctor.
However, this suppository is sold in a few market only like the UK. The suppository has also
been indicated in the treating spasmodic episodes in gynecology.
The price of Phloroglucinol
In France, the consumer has to pay € 2.45 for a supply of 10, 80 mg tablets. In India, the price
of the ingredient, API version of white powder costs USD 130 for a supply of one kilogram of the
powder. In Europe, the price of each suppository is around € 3 euros.
How does it work?
Phloroglucinol exerts its effects most likely by directly inhibiting voltage-dependent calcium
channels of smooth muscle. It can also modulate prostaglandin or nitric oxide release.
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