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Country of origin : Turkey

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acarbose

Tablets 50 mg, 100 mg

Dossier type
CTD
Dossier status
Ready to file
Country of origin
Turkey
GMP approvals
PICS
Manufacturer #13095
This group operates across multiple sectors, including pharmaceuticals, biotechnology, baby nutrition, and animal health. They focus on developing and producing a range of products such as prescription medications, over-the-counter drugs, medical devices, and supplements. While specific therapy areas, dosage forms, GMP certifications, and product patents are not mentioned, their operations span various regions globally, including North America and the EU. The company emphasizes a strong commitment to creating positive work environments and utilizes a meticulous recruitment process for talent acquisition.

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Acarbose

Acarbose belongs to the class of anti-diabetic drugs and it is used to treat type 2 diabetes. It is also used in some countries to treat prediabetes. It works best as a part of the larger proper diet and exercise program. It is vital that the high blood sugar is brought under control because it helps prevent kidney damage, blindness, nerve problems, and other dangerous complications arising out of diabetes. It is also important medicine because the control of diabetes lessens the risk of a heart attack or stroke. Acarbose is a starch blocker, and working by inhibiting the alpha glucosidase, an intestinal enzyme that releases glucose from larger carbohydrates.
Acarbose is sold as a generic in Europe and China under the brand name Glucobay (Bayer AG) and in North America as Precose (Bayer Pharmaceuticals), and in Canada as Prandase (Bayer AG).
In 1990, Bayer AG introduced, the first drug of new type of oral antidiabetic commercialized under the name of acarbose (Glucobay®)30 . Acarbose was first approved for medical use in the United States in 1995 and was the first alpha-glucosidase inhibitor.

Dosing

Acarbose should be taken before the start of main meals as it prevents the digestion of complex carbohydrates, Even the amount of complex carbohydrates in the meal effects the efficacy of Acarbose. An Adult is given a dose of 25 mg 3 times daily, increasing to 100 mg 3 times a day. The maximum daily dosage however the maximum dose per day is 600 mg.

Cost of Acarbose

The cost of Acarbose is cheaper in developing than the developed world. A standard tablet with the strength of 500mg cost USD for generic makers and USD35 for reputed brands. Recent changes in regulation in china bringing down the prices of drugs meant that Acarbose is now available at 93% discount costing only USD1 for one tablet of 50mg.

How does Acarbose work?

Acarbose blocks glycoside hydrolases which are needed in digestion of carbohydrates, specifically, alpha-glucosidase enzymes in the brush border of the small intestines, and pancreatic alpha-amylase. Acarbose works in intestines by slowing down the breakdown and absorption of complex carbohydrates from diet. This effect helps control the rise of blood sugar levels after a meal. Acarbose specifically inhibits those enzymes which help to digest carbohydrates. The Inhibition these enzyme systems decreases the rate of digestion of complex carbohydrates, as are result less glucose is absorbed because the carbohydrates are not broken down into glucose molecules. In patients of type 2 diabities, the short-term effect is to decrease current blood glucose levels and the long-term effect is a reduction in HbA1c level. This is vital because the slowing of food digestion helps keep blood glucose from rising very high after meals.

Finding Acarbose Manufacturers and Suppliers

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