Drug Class: Proton Pump Inhibitors
Chemical Formulation: C17 H19N3O3S
Active Ingredient: Omeprazole
Common/generic brand name: Omeprazole
FDA Approved or not: Yes
Density: 1.4±0.1 g/cm3
Commonly Marketed In: Sweden, US
What is Omeprazole?
Omeprazole is a Proton Pump Inhibitor that decreases the amount of acid produced in the stomach. Omeprazole is used to treat conditions such as gastroesophageal reflux disease (GERD), erosive esophagitis, peptic ulcer disease, Zollinger–Ellison syndrome, upper gastrointestinal bleeding, and eosinophilic esophagitis. It also prevents complications that occur in the long run such as gastric cancer. Health care physicians have been prescribing this drug for a long time to treat these diseases, as it has a safe profile for long-term use.
The active ingredient in this drug is Omeprazole, and other constituents may include Mannitol, Crospovidone, Hypromellose, Poloxamer, Meglumine, Povidone, Methacrylic Acid Ethyl Acrylate Copolymer, Triethyl Citrate, and Magnesium Stearate.
General drug sources for Omeprazole
There is a long list of the general sources of Omeprazole. These include Actavis Labs Fl Inc, Apotex, Aurobindo Pharma Ltd, Breckenridge, Dr. Reddys Labs Ltd, Glenmark Generics, Hetero Labs Ltd Iii, Impax Labs, Lannett Co Inc, Lupin Ltd, Mylan, Sandoz, Teva Pharms USA, Xiromed, Zydus Pharms Usa Inc, AstraZeneca, Dexcel Pharma, Dr. Reddys, Sun Pharm, Spil, Covis, P And L, Perrigo R And D, Ajanta Pharma Ltd, Aurolife Pharma Llc, Guardian Drug, Par Pharm, Sciegen Pharms Inc, Unicorn, Zydus Pharms, Salix, and Bayer Healthcare Llc.
Omeprazole is available in multiple forms:
The oral form of this pharmaceutical drug is available as a capsule, tablet, and suspension. It can be found in strengths of 10 mg,20 mg, 40 mg, and 80 mg. To avoid rapid degradation of the oral formulation in the stomach, most oral forms are enteric-coated. In the US, an immediate-release formulation is also available, which does not require enteric-coating. The suspension form is usually prescribed to children, the elderly, and those with difficulty swallowing.
Another form of Omeprazole that is available is Intravenous injection. The injection pack consists of a vial and an ampule.
How should Omeprazole be used?
Omeprazole should ideally be taken as prescribed by your health physician. This varies based on what the underlying condition is, some generally prescribed doses based on the diseases are:
40 mg orally per day for 4-8 weeks
20 mg orally per day for 4 weeks
20 mg orally per day for 4-8 weeks
Maintenance: 20 mg orally per day up to 1 year
Hypersecretory Conditions (eg, Zollinger-Ellison Syndrome):
60 mg orally per day, can be increased up to 360 mg/day divided as needed. There should be an 8-hour gap between each dose.
If the dose is greater than 80 mg, divide the dose.
These doses may need to be adjusted if you have a co-morbidity such as renal disease or liver disease.
Omeprazole should be taken orally as directed by the physician, 30-60 minutes before your meal. Avoid crushing, chewing, or breaking the tablet or capsule.
Omeprazole Manufacturers and Wholesalers List:
Dexcel Pharma Technologies Ltd
Dr. Reddy's Laboratories Inc
Lannett Company Inc,
Mylan Pharmaceuticals Inc
Sandoz Inc Teva Pharmaceuticals USA, Inc
Sun Pharmaceutical Industries Inc
Glenmark Pharmaceuticals Inc, AvKare Inc
Cost of Omeprazole:
The cost of Omeprazole in the United States of America is as follows: a 40 mg delayed-release capsule costs $0.13- $7.69 per unit, a 20 mg delayed-release capsule costs $0.15-$4.32 per unit, a 10 mg delayed-release capsule costs $0.2-5 $3.13 per unit and a 20 mg delayed-release tablet costs $0.18- $1.09 unit. Omeprazole in powder formulation costs $5.05U per gram.
How to buy Omeprazole on PipelinePharma?
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Side effects of Omeprazole
Side effects are rare, and affect 1% of the population. These include headaches and abdominal pain. It is advised to look out for more adverse effects such as signs of low levels of Magnesium in the blood that may present as a change in the heart rhythm, muscular spasms, and seizures. Another dangerous sign to look out for is drug-induced lupus, which can cause rashes and joint pain. Very rarely Omeprazole may cause Clostridium-difficile associated diarrhea. An allergic reaction with Omeprazole may ensue, although very rare and it can manifest as rash, itching, dizziness, and shortness of breath. With long-term use, Vitamin B-12 deficiency and iron deficiency have also been reported.
Special warning or precaution for use with Omeprazole:
There are certain conditions in which you should be wary of using this medication. This includes allergy to the drug or any drug in its drug class previously or at the time of administration, and history of any severe disease such as lupus, liver disease, or osteoporosis.
Children may be more susceptible to side effects such as fever or cough. Caution is advised when administering Omeprazole in this age group.
Effect of Omeprazole on Pregnancy and Breastfeeding:
The paucity of data related to the risks and benefits of taking Omeprazole during pregnancy and breastfeeding suggests that prescribing Omeprazole to pregnant and lactating mothers should be done if the benefits outweigh the risks. Studies have shown that Omeprazole is secreted into breast milk and hence can be transferred to the baby.
FAQs about Omeprazole
1.What pharmaceutical company makes omeprazole?
The manufacturing of Omeprazole was initiated by Sweden in 1979. The company Astra AB, now AstraZeneca, produced it as an ulcer-treating drug by the name of Losec.
2.Who is the maker of Prilosec?
Prilosec is manufactured by AstraZeneca ( requires a prescription) and Proctor and Gamble (available Over-The-Counter)
3.What is the generic brand for omeprazole?
Omeprazole is the generic name for Prilosec.
4.Where is omeprazole manufactured?
Omeprazole is manufactured in Sweden, the US, India, and Puerto Rico.
5.Is it safe to take omeprazole long-term?
According to doctors worldwide, omeprazole is safe for long-term use.