Alogliptin is to lower blood sugar levels in patients with type 2 diabetes, a condition in which blood sugar is too high because the body does not produce or use insulin normally. It is used in conjunction with prescribed diet and exercises. However, Alogliptin is not used to treat type 1 diabetes or diabetic ketoacidosis. Like other members of it family of drugs, patients using Alogliptin gain little or no weight, and has relatively modest glucose-lowering ability.
Over time, Diabetics develop life-threatening conditions or complications like heart diseases, and stroke, kidney issues, nerve damage, and eye problems. Alogliptin therapy decreases the odds of suffering a heart attack or stroke, or diabetes-caused ailments like kidney failure, nerve damage leading to numbness, cold feet and decreased libido in men and women and eye problems, including loss of vision, or even gum disease.
Alogliptin is sold under the brand name Nesina® amongst others. Other brand names with combination products include Kazano® (containing Alogliptin, Metformin) and Oseni® (containing Alogliptin, Pioglitazone).
Takeda Pharmaceutical Company submitted a New Drug Application (NDA) to USFDA in December 2007. After success in positive results from Phase III clinical trials, in September 2008, Takeda Pharmaceutical also filed for approval in Japan winning approval in April 2010. The first USFDA NDA did not get approval and was followed by a pair of NDAs but in 2012, they did not get the approval citing insufficient evidence.
How much will I take?
Alogliptin is sold as tablets in the increasing strength of 25mg, 12.5mg or 6.25mg tablets. The usual dose prescribed for adults is 25mg a day. For patients also suffering from kidney isssues, the dosage is kept low at 12.5 mg or even 6.25 mg/day.
The price of Alogliptin
Patients can buy a Nesina oral tablet 6.25 mg costs around $300- $424 for a supply of 30 tablets that is $14 per tablet at the higher end. The cost of Alogliptin varies hugely around the world with as low as $5 per the same tablet. The cost of Alogliptin is in general lower in the developing world compared to the developed countries.
How does it work?
Alogliptin is in a class of medications called dipeptidyl peptidase-4 inhibitors. Alogliptin works by increasing the amount of insulin that body cannot make. Insulin is the hormone that controls sugar levels in blood. Alogliptin inhibits the incretins, thus increasing the amount of active plasma incretins, which in turn helps regain glycemic control.
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Takeda Pharmaceuticals America, Inc. Perrigo New York Inc Aphena Pharma Solutions - Tennessee, LLC
Brand names: Nesina, Vipidia; Kazano, Vipidomet (with metformin); Oseni, Incresync (with pioglitazone)