Calcipotriol

Calcipotriol also called Calcipotriene is a synthetic derivative of Calcitriol. It is a form of vitamin D. Calcipotriol is used to treat psoriasis. Amongst its main advantages is that that is safe for long-term application in psoriatic skin conditions and alopecia areata. Psoriasis makes skin cells multiply up to 10 times faster than normal resulting in excess skin build-up into bumpy red patches covered with white scales. They mostly grow on the scalp, elbows, knees, and lower back. Calcipotriol is marketed under the brand names Dovonex, Daivonex and Psorcutan amongst others. Sterling Drug Inc first patented Calcipotriol in 1985 and approved for medical use in 1991. Since then there have been several formulations and innovations patented for this medicine.

Forms and dosage:

Calcipotriol is available as a topical ointment, topical cream, topical foam. When treating Plaque Psoriasis using Ointment or Cream, apply a thin layer of cream to the affected area. When using the Solution Indicated for chronic problems, moderately severe psoriasis of the scalp, apply the indicated solution to the affected area.

The price of Calcipotriol:

In the USA, consumers pay around $149 for calcipotriene topical cream 0.005%, for a supply of 60 grams. The prices are cheaper in the developing world. In India, Ointment of 20gm cost USD3.6 and the 0.005% cream costs USD7.

How does Calcipotriol work?

Calcipotriol’s efficacy in the treatment of psoriasis was first noticed by the observation of patients receiving various forms of vitamin D. Patients suffering from psoriasis experienced dramatic reductions in lesion counts. The precise mechanism of calcipotriol in unknown.

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