Carmustine is known by the brand name Bicnu, used to treat some types of cancer (such as multiple myeloma, brain tumors, Hodgkin's disease, and non-lymphoma). This drug is an alkylating agent, which is a type of medication. This pharmaceutical medicine is often administered through vein infusion (intravenous, IV). This drug does not come in pill form. After surgical removal of a brain tumor, a type of this drug can be implanted and kept in the cavity. Carmustine allows the medicine to be delivered directly to the site of the brain tumor. This drug has known serious interactions with other drugs including influenza virus vaccine quadrivalent, adjuvanted, influenza virus vaccine trivalent, adjuvanted, Palifermin, and Tofacitinib. Common side effects associated with this pharmaceutical medicine include vomiting and nausea, flushing of the face, pain and burning at the site of injection, blood counts are low. Some less common (occurring in 10-29 percent of patients) include anemia, low blood pressure (hypertension) caused by high-dose treatment, dizziness, disorientation and loss of coordination, problems with the eyes including transient redness and/or blurring, as well as retinal hemorrhage. It is not recommended for use by pregnant women, as the drug can cause fetal harm. There is no data on the presence of this drug in human milk or the effects on breastfed children or milk production; because of the possibility of serious adverse reactions in breastfed children from therapy, women are advised not to breastfeed during treatment.

Carmustine induces DNA and RNA cross-linking, which inhibits DNA synthesis, RNA production, and RNA translation (protein synthesis). This drug also attaches to and alters glutathione reductase resulting in cell death.

The cost of Carmustine intravenous powder for injection 100 mg is roughly $2,763 for a supply of 1 intravenous powder.

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