Clomiphene Citrate

Clomiphene Citrate treats infertility in women. Clomiphene Citrate increases the amount of hormones that support the growth and release of a mature egg or better known as ovulation. Clomiphene is a synthetic chemical, it works by binding to estrogen receptors in the brain which causes pituitary FSH levels to rise. Gonadotropins just like human protein hormones FSH and LH bypass the pituitary gland and directly stimulate the ovaries. Women, whose ovaries no longer make eggs properly, due to primary pituitary or ovarian failure, should not take this medication.

Clomiphene Citrate is sold under the brand names Clomid & Serophene. Several underlying conditions hamper body's ability to ovulate effectively. The best way so far to treat the conditions by stimulating the ovarian follicles to produce multiple eggs in one cycle using medication. The two most common fertility medications for this issue is Clomiphene Citrate and Gonadotropins.

Clomiphene Citrate is sold under the brand name Clomid and Serophene amongst others. Sanofi-Aventis U.S. LLC, which holds the current patent, got the nod from USFDA in 2012. However, Clomifene was first approved for medical use in 1967.

Dosage and administration

Clomiphene citrate is sold as at tablet of 50mg strength. It is used in conjunction with a Provera, increasing the effectiveness in initiating menstruation and ovulation in women with no menstrual cycle. The recommended dose is clomiphene citrate 50 mg tablet, taken orally for 5 days. Ultrasound monitoring determines ovarian follicle or follicles development on 11 or 12 day of the menstrual cycle. During this time, a ovulation predictor kit is used to test urine for a surge in luteinizing hormone, indicating maturation of eggs and the imminent ovulation. Following which, either artificial insemination or intercourse are time to coincide with ovulation. Patients then taken a pregnancy (urine) test, two weeks after the ovulation to confirm results.

The cost of Clomiphene Citrate

In Australia, the consumers have to pay retail price of about $20 for a box of 30 tablets. In the USA, the consumers have to pay USD100 for a supply 30 tablets of 50mg strength. The cost of this medicine is much lower in the developing world.

How does Clomiphene Citrate work?

Clomiphene actions trigger pituitary gland in the brain to release increased amount of follicle stimulating hormone and Luteinizing hormone. The overall result of its actions stimulate growth of the ovarian follicle and thus initiates ovulation. In addition, the use of Clomiphene often causes the ovaries to produce two or three eggs per cycle, instead of the one release during a normal menstrual cycle.

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