Felodipine

Felodipine is used to treat high blood pressure or hypertension and stable angina. Its main role is to lower high blood pressure which prevents strokes, heart attacks, and kidney issues. Felodipine is a calcium channel blocker, which by blocking the calcium channel relaxes and widens blood vessels so for the blood to flow more easily. Felodipine is sold under many brand names like Auronal, Cardioplen, Catrazil worldwide. Pregnant women should use Felodipine, or those with acute heart failure, are having a heart attack, obstructed heart valve, or have blood flow obstructions that block flow in the heart. Hässle, a division of Astra AB discovered and filed for a patent in 1979 for use as an antihypertensive drug. It later came into sales in 1988. Later, under a 1982 agreement between Astra and Merck & Co, the FDA approved a drug in 1991. After the expiry of the initial patent, the first generics were in Sweden and the US starting 2003. In 2016, China Medical System Holdings bought the right for marketing from AstraZeneca.

Dosage and administration

Felodipine is sold as Tablets and extended-release in the increasing strengths of 2.5 mg, 5 mg, and 10 mg. In the treatment of Hypertension, the initial recommended adult dose is 2.5 to 5 mg, taken orally, once a day. This was followed by a maintenance dose of 2.5 to 10 mg, daily, taken orally and in some cases the doctors even recommend up to 20 mg dose each day. In the elders, the Initial dose is 2.5 mg, with dosage adjusted at intervals of at least 2 weeks.

The cost of Felodipine

In the USA, the consumers pay a cost of $44 supply of 90 tablets of oral or extended-release 2.5mg. In, India, As the drug is manufactured by generic makers, it costs USD 0.85 for 1 tablet of 5 mg, whereas the branded formulation costs USD 1.2 for 10 tablets of 5mg.

How does Felodipine Work?

Felodipine is a calcium channel blocker and has additionally been an antagonist of the mineralocorticoid receptor, or as an antimineralocorticoid. Vascular and cardiac tissue has various calcium channels. Felodipine works in three steps, through which it is able to block the calcium channels, this leads to relaxation of muscles allowing for a freer flow of blood, resulting in less stress on the heart, thus lowering the blood pressure.

Finding Felodipine Manufacturers and Suppliers

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