Loxoprofen sodium

Loxoprofen sodium belongs to the propionic acid derivatives group. It is a nonsteroidal anti- inflammatory drug much like ibuprofen and naproxen. Loxoprofen sodium reduces inflammation and pain in patients suffering from rheumatoid arthritis, osteoarthritis, lumbar pain, frozen shoulder, neck-shoulder-arm syndrome, tooth pain, as well as after surgery, wounds, or tooth removal. Loxoprofen sodium is marketed in Brazil, Mexico, and Japan Loxonin, in Argentina as Oxeno and in India as Loxomac among others. It is also sold as a drug for oral use in some countries. Sankyo received approval for a transdermal preparation for sale in Japan in 2006, followed by tape and gel formulations in 2008 and 2010 respectively. Sankyo Company Limited patented it in 1977 and approved it for medical use in the USA in1986.

Dosage and administration

Loxoprofen sodium is available as tablets of 60mg and transdermal patches. The usual recommended adult dose is one 60 mg tablet, taken orally at a time, 3 times a day. This medicine should be taken with food or immediately after meals.

The price of Loxoprofen sodium

In Japan, the consumer has to pay between US$24.49 for a supply of 100, 60mg tablets. In the API market, the medicine grade powder of Loxoprofen sodium costs around USD160 per kilo.

How does it work?

Loxoprofen sodium is an NSAID b ut a prodrug. It has similar actions to other NSAIDs. It non- selectively inhibits cyclooxygenase and reduces the synthesis of prostaglandins from arachidonic acid. 3 Cyclooxygenase found in 2 forms, COX-1 and COX-2, serve different functions. COX-1 is constitutively released and is involved in cellular housekeeping functions like mucus production and platelet aggregation. COX-2 is induced in cells after an injury or due to other stimuli and appears in large quantities in the injury site or stimuli. They are responsible for mediating inflammation and pain. By inhibiting COX isoforms, it reduces the expression of several mediators of pain, inflammation, and fever.

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