What does it do? Methylene blue, also known as Methylthioninium chloride, is a medication used primarily in the treatment of Methemoglobinemia. In this condition, the blood lose its ability to supply oxygen through the body. It is specifically used to treat patients with above condition, when the regular therapies have failed to work. In the past, it has also been used to treat cyanide poisoning and urinary tract infections. In combination with other formulations, it is also used in the treatment of other ailments. In combination with light, it is used to cure plaque psoriasis. Methylene blue has also been used as a placebo in the past. Doctors tells patients to expect changes in the colors of their stools and urine and the change is seen as a sign of body healing. Methylene blue is sold under the brand name Provayblue, Urolene Blue amongst some of its commonly used names. It is manufactured and sold in all major continents and countries given its life saving ability, Other popular brand names include Urimax, Cystemms-V, Urapine, Dolsed, Uribel, Uretron DS, Uro-MP, Urin D/S used to treat UTIs. Other common brand names include Methylphen, Urised, Hyophen, Prosed DS. In 1876, Heinrich Caro created Methylene blue. Due to its life saving ability and efficacy, if features on the World Health Organization's List of Essential Medicines. It has a dark green in color, in powder form and has no odor. Methylene blue makes blue colored solution when dissolved in water. In 2019, the wholesale cost of Methylene blue in United States, for a 50 mg vial is US$191. Whereas in the UK, a 50 mg vial costs £39. Dosage: Methylene blue is typically injected into a vein through an IV and takes about 30 minutes. Patients vital signs are monitored they are getting the methylene blue. Blood is also tested to make sure that the medicine is actually working. A single dose is 5mg/mL (50mg/10mL) single-dose ampule. However, if the methomoglobin levels remain above 30%, the dose is repeated after an hour. The dosage is based on the lean body weight and the treatment last no more than one day. How does it work? Hemoglobin, a ferrous substance in our blood carries oxygen to all our tissues and organs. Methemoglobin is another type of hemoglobin but it does not carry oxygen. When the level of Methemoglobin increase our body, the blood is no more able to carry oxygen efficiently to all it organs. This resulting lack of oxygen in the body can have some very serious ill effect on our health. Methylene blue works by converting this harmful form of Hemoglobin to a more efficient type of hemoglobin so that it can carry oxygen throughout the body efficiently. Finding Methylene Blue Manufacturers and Suppliers: The process of finding trusted Methylene Blue manufacturers and Methylene Blue suppliers can be made quicker and more accessible by using Pipelinepharma's online platform, a B2B marketplace that lets you finalize the deals of pharmaceutical products in a matter of a few clicks. Also, it is an easy to use online platform to grow your business opportunities. The robust search engine makes it convenient to search for manufacturers and suppliers of Methylene Blue. The search can be further refined with industry-specific filters such as dossier type, country of origin, GMP approvals, and search criteria for Wholesaler, etc. helping to get in contact with the preferred manufacturer and supplier readily. Manufacturers of Methylene Blue: Macsen Laboratories in India PROVEPHARM SAS in France Mikrochem in Slovakia Suppliers Duchefa Farma B.V. from Netherlands Azacus Strategy Consultants Private Limited from India In the USA BOC sciences Dudley chemical corp Creative Enzymes Marketers of Methylene Blue ANSHI CHEMICALS PVT. LTD., Sakshi Dyes and Chemicals, DAIICHI SANKYO COMPANY, LIMITED, Megha International, Shreeji Pharma International, Ashaway Line & Twine Mfg. Co., Belami Laboratory & Fine Chemicals, MACSEN GROUP, COSMO Pharmaceuticals, A & C American Chemicals Ltd., A&K Petro - Chem Industries Limited, ACP Chemicals Inc., Alfa Aesar, Bio-Rad Laboratories (Canada) Ltd., Caledon Laboratories Ltd., Canadawide Scientific Ltd., Cedarlane and Cleartech Industries Inc among others.