Nebivolol Hydrochloride

Nebivolol is a beta-blocker that is used in the treatment of high blood pressure and heart failure. Like all β-blockers, Nebivolol Hydrochloride is generally a less preferred treatment for high blood pressure. It can be taken alone or in combination with other medicines used for this purpose. Nebivolol Hydrochloride actions block β1-adrenergic receptors in the heart and dilating blood vessels. Pregnant women are recommended against taking this medicine. Nebivolol is available as Nebula, Nebizok, and Bystolic among others.  Janssen Pharmaceutica N.V. filed for the first patent and was received in 1983. It came into medical use in 1997. However, in 2001, Mylan Laboratories licensed the rights to the U.S. and Canadian market from Janssen Pharmaceutica N.V. in the USA, it is made by Forrest pharmaceuticals.

Forms and Dosage:

  Nebivolol is sold as a tablet for oral administration. It can be taken with or without the combination of other drugs. In the treatment of high blood pressure, the usual recommended adult dosage for people older than 18 years is 5 mg once per day. The dosage of this drug is adjusted as per the patient’s response. These dose adjustments are usually done two weeks apart. The maximum allowed daily dose should not exceed 40mg.

The price of Nebivolol HCL:

In the United Kingdom, A month supply costs about £0.89 as of 2019. In the United States, the consumer has to pay a wholesale cost of US$128.00 for a supply of 100 tablets of 5mg strengths. In India, a supply of 100 tablets of 5mg costs around USD3.

How does Nebivolol HCL work?

Nebivolol HCL belongs to a class of drugs called beta-blockers. Beta-blockers actions relax blood vessels. The relaxation reduces the workload on the heart and slows down the heart rate. As a result, blood pressure is lowered. More specifically, Nebivolol is a beta-1 adrenergic receptor antagonist that also has antihypertensive and vasodilatory properties. Nebivolol binds to and thus can block beta-1 adrenergic receptors in the heart. It decreases cardiac contractility and rate. Eventually, this decrease leads to a reduction in cardiac output and lowers blood pressure.   

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